Quantitative analysis of glycated albumin in serum based on ATR-FTIR spectrum combined with SiPLS and SVM.

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Yuanpeng LiShifu Zheng

Abstract

A rapid quantitative analysis model for determining the glycated albumin (GA) content based on Attenuated total reflectance (ATR)-Fourier transform infrared spectroscopy (FTIR) combining with linear SiPLS and nonlinear SVM has been developed. Firstly, the real GA content in human serum was determined by GA enzymatic method, meanwhile, the ATR-FTIR spectra of serum samples from the population of health examination were obtained. The spectral data of the whole spectra mid-infrared region (4000-600 cm-1) and GA's characteristic region (1800-800 cm-1) were used as the research object of quantitative analysis. Secondly, several preprocessing steps including first derivative, second derivative, variable standardization and spectral normalization, were performed. Lastly, quantitative analysis regression models were established by using SiPLS and SVM respectively. The SiPLS modeling results are as follows: root mean square error of cross validation (RMSECVT) = 0.523 g/L, calibration coefficient (RC) = 0.937, Root Mean Square Error of Prediction (RMSEPT) = 0.787 g/L, and prediction coefficient (RP) = 0.938. The SVM modeling results are as follows: RMSECVT = 0.0048 g/L, RC = 0.998, RMSEPT = 0.442 g/L, and Rp = 0.916. The results indicate...Continue Reading

Citations

Apr 15, 2020·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Farzad SeidiChangsheng Zhao
Dec 18, 2020·Applied Spectroscopy·Kamila KochanBayden R Wood
May 29, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Wenyu PengChao Chang

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