PMID: 8938540Nov 1, 1996Paper

Quantitative analysis of IgM anti-HBc in chronic hepatitis B patients using a new "gray-zone" for the evaluation of "borderline" values

Journal of Hepatology
G ColloredoF Bonino

Abstract

In order to define the clinical significance of borderline levels of IgM anti-HBc in chronic hepatitis B patients, we followed up 89 untreated hepatitis B patients (19 HBeAg pos and 70 anti-HBe pos) for 1 year, with monthly monitoring of IgM anti-HBc using a highly sensitive quantitative microparticle enzyme immunoassay (IMx CORE-M, Abbott). As a control group we used 304 healthy subjects: 150 HBsAg negative and anti-HBc/anti-HBs positive, and 154 without markers of HBV infection. The statistical analysis performed by Receiver Operating Characteristic curve indicated the 100% sensitivity cut-off at 0.081 IMx index and 100% specificity cut-off at 0.358 IMx index. We could define the range of a chronic hepatitis B "gray-zone" between 0.100 [80.6% specificity (95% CI, 76.2%-85%), 96.6% sensitivity (95% CI, 92.8%-100%)] and 0.200 [95.7% specificity (95% CI, 93.4%-98%) and 78.7% sensitivity (95% CI, 70.2%-87.2%)] of the IgM anti-HBc-IMx index. In fact, none of the chronic hepatitis B patients had IgM anti-HBc-IMx values persistently below 0.100 during the follow-up, whereas 57.3% had values persistently higher than 0.200. In 38.2%, IgM anti-HBc values occasionally fell within the "gray-zone" limits. In the remaining four patients (4...Continue Reading

References

Jan 1, 1992·Journal of Medical Virology·H M SmithR Williams
May 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M H SjogrenJ G Waggoner
Mar 1, 1985·Annals of Internal Medicine·S C GordonE R Schiff
Jul 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M H SjogrenJ H Hoofnagle
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J NowickiD Stevenson
Sep 1, 1983·The Journal of Infectious Diseases·M H Sjogren, S M Lemon

❮ Previous
Next ❯

Citations

Jan 8, 2004·Journal of Hepatology·Giovanni RaimondoGiovanni Squadrito
Jan 8, 2004·Journal of Hepatology·Ferruccio Bonino, Maurizia Rossana Brunetto
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S J Hadziyannis, D Vassilopoulos
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Ann SöderströmMagnus Lindh
Jul 30, 2014·PloS One·Anika WrankeUNKNOWN HIDIT-2 Study Group
Feb 6, 2009·World Journal of Gastroenterology : WJG·Maurizia Rossana BrunettoFerruccio Bonino
Mar 21, 2002·Expert Review of Molecular Diagnostics·F BoninoM R Brunetto
May 6, 2010·Wiener klinische Wochenschrift·Markus Peck-RadosavljevicWolfgang Vogel
Oct 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Doan Y DaoUNKNOWN Acute Liver Failure Study Group
Aug 9, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anna RodellaNino Manca
May 25, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Irene CacciolaGiovanni Raimondo
Mar 15, 2005·Scandinavian Journal of Infectious Diseases·Ann SöderströmGunnar Norkrans
Jan 27, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jing PengZiyong Sun
Nov 2, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L O SouzaL C da Silva
May 24, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G Carosi, M Rizzetto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.