Quantitative analysis of intracellular communication and signaling errors in signaling networks

BMC Systems Biology
Iman HabibiAli Abdi


Intracellular signaling networks transmit signals from the cell membrane to the nucleus, via biochemical interactions. The goal is to regulate some target molecules, to properly control the cell function. Regulation of the target molecules occurs through the communication of several intermediate molecules that convey specific signals originated from the cell membrane to the specific target outputs. In this study we propose to model intracellular signaling network as communication channels. We define the fundamental concepts of transmission error and signaling capacity for intracellular signaling networks, and devise proper methods for computing these parameters. The developed systematic methodology quantitatively shows how the signals that ligands provide upon binding can be lost in a pathological signaling network, due to the presence of some dysfunctional molecules. We show the lost signals result in message transmission error, i.e., incorrect regulation of target proteins at the network output. Furthermore, we show how dysfunctional molecules affect the signaling capacity of signaling networks and how the contributions of signaling molecules to the signaling capacity and signaling errors can be computed. The proposed approac...Continue Reading


Nov 20, 2002·Annals of the New York Academy of Sciences·José-María Trifaro
Apr 2, 2003·Cell Biology Education·Bruce Alberts, National Academies
Oct 31, 2003·Cancer Cell·Ji LuoLewis C Cantley
Jan 28, 2004·Nature Genetics·Effat S EmamianJoseph A Gogos
May 8, 2004·Trends in Biochemical Sciences·Derek P BrazilBrian A Hemmings
Apr 20, 2006·Infection and Immunity·John T Loh, Timothy L Cover
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thanh V NguyenGen-Sheng Feng
Aug 29, 2007·PLoS Computational Biology·Julio Saez-RodriguezBurkhart Schraven
Feb 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tomás HelikarJim A Rogers
Jul 15, 2009·Nature Methods·Hani GoodarziSaeed Tavazoie
Mar 17, 2010·Biochemistry·Melody K MorrisDouglas A Lauffenburger
Jun 10, 2010·Molecular Systems Biology·Sona PandeyRéka Albert
Jun 10, 2010·Molecular Systems Biology·Hani GoodarziSaeed Tavazoie
Mar 24, 2011·BMC Systems Biology·Rui-Sheng Wang, Réka Albert
Oct 22, 2011·Briefings in Bioinformatics·Rebekka SchlatterThomas Dandekar
Dec 7, 2011·Methods in Molecular Biology·Claudine ChaouiyaDenis Thieffry
Sep 27, 2012·Physical Biology·Rui-Sheng WangRéka Albert
Oct 18, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Michelle L WynnSantiago Schnell
Nov 13, 2012·Methods : a Companion to Methods in Enzymology·Assieh Saadatpour, Réka Albert
Jun 1, 2013·Bulletin of Mathematical Biology·Claudine Chaouiya, Elisabeth Remy
Jun 28, 2013·Cell Communication and Signaling : CCS·Regina Samaga, Steffen Klamt
Sep 7, 2013·EURASIP Journal on Bioinformatics & Systems Biology·Guy Karlebach
Sep 24, 2013·BioMed Research International·Koichi Kobayashi, Kunihiko Hiraishi
Sep 27, 2013·PloS One·Maria I Davidich, Stefan Bornholdt

Related Concepts

Signal Transduction
Subcellular Space
Plasma Membrane
Cell Nucleus
Objective (Goal)
Ion Channel

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.