Quantitative analysis of intracellular communication and signaling errors in signaling networks

BMC Systems Biology
Iman HabibiAli Abdi

Abstract

Intracellular signaling networks transmit signals from the cell membrane to the nucleus, via biochemical interactions. The goal is to regulate some target molecules, to properly control the cell function. Regulation of the target molecules occurs through the communication of several intermediate molecules that convey specific signals originated from the cell membrane to the specific target outputs. In this study we propose to model intracellular signaling network as communication channels. We define the fundamental concepts of transmission error and signaling capacity for intracellular signaling networks, and devise proper methods for computing these parameters. The developed systematic methodology quantitatively shows how the signals that ligands provide upon binding can be lost in a pathological signaling network, due to the presence of some dysfunctional molecules. We show the lost signals result in message transmission error, i.e., incorrect regulation of target proteins at the network output. Furthermore, we show how dysfunctional molecules affect the signaling capacity of signaling networks and how the contributions of signaling molecules to the signaling capacity and signaling errors can be computed. The proposed approac...Continue Reading

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Related Concepts

Engineering
Ligands
T-Lymphocyte
Signal Transduction
Subcellular Space
Procaspase-3
Plasma Membrane
Cell Nucleus
Objective (Goal)
Ion Channel

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