PMID: 9191884Jul 1, 1997Paper

Quantitative analysis of leukocyte membrane antigen expression on human fetal and cord blood: normal values and changes during development

Clinical Immunology and Immunopathology
A BikoueJ Sampol

Abstract

We studied the antibody binding capacity (ABC) of various cell-surface antigens in normal human fetuses and term neonates on lymphocyte, monocyte, and polymorphonuclear (PMN) cells by quantitative flow cytometry also designated by quantimetry. Analysis of changes of expression level on these leukocytes during the developmental process was also investigated. The results indicated that the ABC values of most studied markers change during the maturational process. The ABC of lymphocyte-associated antigens studied such as CD5 and CD7 showed only a decrease from fetus to adult, whereas according to the type of molecule on monocyte and PMN there was either an increase or a decrease of ABC values dependent on the stage of the developmental process, from fetus to neonate or from neonate to adult. However, the ABC values of leukocyte membrane antigens such as CD16, CD46, and CD55 on all leukocytes and CD11b, CD11c, and CD35 on myeloid cells did not change. Their expression level was already mature in fetuses compared with adult cells. In addition, in this quantimetric approach, the analysis of the results for CD11a and CD8 suggested that the changes of CD11a expression level on lymphocyte subsets can depend on one mechanism, whereas the...Continue Reading

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Citations

Jul 31, 2013·Acta Pharmacologica Sinica·Fudong Liu, Louise D McCullough
Dec 18, 2001·Environmental Health Perspectives·H Tryphonas
Jun 7, 2011·Journal of Reproductive Immunology·Claudia Nussbaum, Markus Sperandio
Dec 1, 2009·Biotechnology Journal·Kornelia SchrieblAlois Jungbauer
Jan 26, 2016·Scandinavian Journal of Immunology·Ranjini ValiathanDeshratn Asthana
Jun 10, 2016·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Isabel RauscherMatthias Eiber
Jun 13, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Carla R ScaliaGiorgio Cattoretti
Dec 13, 2003·Analytical Chemistry·Kara E McCloskeyMaciej Zborowski

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