Abstract
The objective of this study was to analyze the characteristics of lymphatic vasculature in normal and (peri)tumoral prostate tissue, applying accurate and objective quantification techniques based on digital image analysis. Radical prostatectomy specimens of 27 patients were selected containing organ confined peripheral zone tumors, which were restricted to one side of the prostate (pT2a). Lymph vessels were visualized by immunohistochemistry against D2-40. Lymphatic vessel density, perimeter, and area were assessed over the entire tumor and corresponding contralateral normal tissue. Also, morphology (area, perimeter, and diameter) of individual lymph vessels were measured in (peri)tumoral and normal tissue. No differences were found in the overall lymph vasculature between tumor and normal peripheral zone. However, the area, perimeter, and diameter of individual lymph vessel profiles were significantly decreased in (peri)tumoral as compared to normal tissue. No differences were seen for these parameters between peritumoral and tumoral area. Comparing the coefficient of variation between compartments (normal, (peri)tumoral), no differences were observed for any parameter. Although differences exist between the morphology of ind...Continue Reading
References
Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·P S Tofts
Aug 22, 2000·The Prostate·H FukudaH Saitoh
Feb 13, 2001·Microvascular Research·N EbataS Yoshida
Sep 10, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Harriette J Kahn, Alexander Marks
Jan 30, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J ValencakH Pehamberger
May 29, 2004·Virchows Archiv : an International Journal of Pathology·Femke VlemsHan van Krieken
Jun 18, 2004·The Journal of Urology·Lutz TrojanRainer Grobholz
Dec 17, 2004·The Prostate·Shigehiro SohShiro Baba
Jun 11, 2005·The Prostate·Yiping ZengElizabeth D Williams
Aug 13, 2005·The American Journal of Surgical Pathology·Jonathan I EpsteinUNKNOWN ISUP Grading Committee
Jan 10, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andres A RomaMing Zhou
Sep 19, 2006·BJU International·Lutz TrojanMaurice S Michel
Feb 21, 2008·Human Pathology·Liang ChengRodolfo Montironi
Sep 10, 2008·The Prostate·Cornelis G van NiekerkChristina A Hulsbergen-van de Kaa
Dec 9, 2008·Pathology, Research and Practice·Hyun-Soo KimYong-Koo Park
May 13, 2010·Histopathology·Inge M van OortChristina A Hulsbergen-van de Kaa
Citations
Jul 19, 2014·European Radiology·Cornelis G van NiekerkChristina A Hulsbergen-van de Kaa
Sep 16, 2014·Pathology, Research and Practice·Aleksandra StrzępekKrzysztof Okoń
Oct 17, 2012·Human Pathology·Maria TretiakovaAytekin Oto