Quantitative analysis of mebendazole polymorphs in pharmaceutical raw materials using near-infrared spectroscopy

Journal of Pharmaceutical and Biomedical Analysis
Vitor H da SilvaClaudete Fernandes Pereira

Abstract

This work evaluates the feasibility of using NIR spectroscopy for quantification of three polymorphs of mebendazole (MBZ) in pharmaceutical raw materials. Thirty ternary mixtures of polymorphic forms of MBZ were prepared, varying the content of forms A and C from 0 to 100% (w/w), and for form B from 0 to 30% (w/w). Reflectance NIR spectra were used to develop partial least square (PLS) regression models using all spectral variables and the variables with significant regression coefficients selected by the Jack-Knife algorithm (PLS/JK). MBZ polymorphs were quantified with RMSEP values of 2.37% w/w, 1.23% w/w and 1.48% w/w for polymorphs A, B and C, respectively. This is an easy, fast and feasible method for monitoring the quality of raw pharmaceutical materials of MBZ according to polymorph purity.

References

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Jan 18, 2011·Journal of Pharmaceutical and Biomedical Analysis·Norman ChiengJaakko Aaltonen

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Citations

Feb 15, 2016·Journal of Pharmaceutical and Biomedical Analysis·Natalia L CalvoRubén M Maggio
Dec 13, 2016·Journal of Pharmaceutical and Biomedical Analysis·Vitor Hugo da SilvaClaudete Fernandes Pereira
Jul 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lun WuGenhong Cheng
Apr 12, 2021·Carbohydrate Polymers·Shusaku NakajimaYuichi Ogawa

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