PMID: 8588057Jul 1, 1995Paper

Quantitative analysis of neuropathologic changes in the cerebral cortex of centenarians

Progress in Neuro-psychopharmacology & Biological Psychiatry
P GiannakopoulosC Bouras

Abstract

1. The quantitative distribution of neurofibrillary tangles and senile plaques was studied in the brains of 65 elderly patients aged from 96 to 104 years by immunohistochemistry. 2. According to the clinical and neuropathological diagnoses, three groups of cases were considered: 19 patients with Alzheimer's disease, 22 patients with mixed dementia (vascular and degenerative) and 24 patients with no or very mild cognitive impairment. 3. Moderate to high neurofibrillary tangle densities were always present in the hippocampus and entorhinal cortex. The inferior temporal cortex was very frequently affected in demented and non-demented cases whereas the superior frontal cortex was spared in the majority of cases independently of the clinical diagnosis. Quantitatively, Alzheimer's disease cases showed significantly higher NFT densities than cases with no clinical findings of dementia only in the CA1 field of the hippocampus. 4. The hippocampus and entorhinal cortex were often devoid of senile plaques in non-demented cases while the vast majority of Alzheimer's disease cases had few SP in these regions. The frontal and temporal cortex were more frequently involved than the limbic structures in both non-demented and Alzheimer's disease...Continue Reading

References

Aug 1, 1992·International Journal of Epidemiology·K RitchieJ M Robine
Apr 1, 1992·Journal of the Neurological Sciences·T Mizutani, H Shimada
Jul 1, 1992·Journal of Neuropathology and Experimental Neurology·E MasliahR D Terry
Apr 1, 1990·Neuropathology and Applied Neurobiology·B M HubbardJ M Anderson
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R C PearsonT P Powell
Sep 1, 1970·Journal of the Neurological Sciences·B E TomlinsonM Roth
Sep 1, 1968·Journal of the Neurological Sciences·B E TomlinsonM Roth
Jan 1, 1983·Neurobiology of Aging·C Q MountjoyH M Evans
Aug 1, 1981·Annals of Neurology·R D TerryD S Horoupian

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Citations

Sep 10, 2008·Archives of Neurology·Vahram HaroutunianHillel T Grossman
Mar 6, 2010·Acta Neuropathologica·Kurt A Jellinger, Johannes Attems
Oct 17, 2001·Experimental Gerontology·I Irminger-Finger, C Sieber
May 7, 2009·Brain : a Journal of Neurology·Christos DavatzikosSusan M Resnick
Sep 28, 2010·Journal of the Neurological Sciences·Kurt A Jellinger, Johannes Attems
Nov 26, 2015·Neurobiology of Aging·Janna H NeltnerPeter T Nelson
May 27, 2011·Annals of the New York Academy of Sciences·Enikö KövariConstantin Bouras
Apr 24, 2001·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·K Andersen-RanbergB Jeune
Oct 20, 2017·Neurology·Michel J GrotheUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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