Quantitative analysis of population-scale family trees with millions of relatives

Science
Joanna KaplanisYaniv Erlich

Abstract

Family trees have vast applications in fields as diverse as genetics, anthropology, and economics. However, the collection of extended family trees is tedious and usually relies on resources with limited geographical scope and complex data usage restrictions. We collected 86 million profiles from publicly available online data shared by genealogy enthusiasts. After extensive cleaning and validation, we obtained population-scale family trees, including a single pedigree of 13 million individuals. We leveraged the data to partition the genetic architecture of human longevity and to provide insights into the geographical dispersion of families. We also report a simple digital procedure to overlay other data sets with our resource.

References

Jan 1, 1978·American Journal of Medical Genetics·P Philippe
Nov 21, 1998·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·B LjungquistN L Pedersen
Mar 21, 2000·American Journal of Human Genetics·M AbneyC Ober
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R A KerberR M Cawthon
Aug 15, 2001·American Journal of Medical Genetics·B D MitchellA R Shuldiner
Oct 9, 2001·American Journal of Human Genetics·C OberM S McPeek
May 11, 2002·Science·Jim Oeppen, James W Vaupel
Dec 15, 1954·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·O KEMPTHORNE
Mar 12, 2004·Nature·Mirkka LahdenperäAndrew F Russell
Apr 4, 2007·Molecular Ecology·L J Lawson Handley, N Perrin
Dec 13, 2007·Human Heredity·Lisa A Cannon Albright
Jan 19, 2008·Genetics·Rodrigo Labouriau, António Amorim
Feb 9, 2008·Science·Agnar HelgasonKári Stefánsson
Mar 6, 2008·Nature Reviews. Genetics·Peter M VisscherNaomi R Wray
May 31, 2008·American Journal of Public Health·Felix Elwert, Nicholas A Christakis
Jan 8, 2009·Journal of the American Medical Informatics Association : JAMIA·Lucia Ohno-Machado, Randolph A Miller
Jan 24, 2009·Nature Genetics·Augustine KongKari Stefansson
Feb 11, 2009·Molecular Biology and Evolution·Turi E King, Mark A Jobling
May 13, 2009·Nature Reviews. Genetics·Heather J Cordell
Dec 18, 2009·Nature·Augustine KongKari Stefansson
Jan 15, 2010·Annual Review of Public Health·Rodolfo ValdezMuin J Khoury
Aug 4, 2011·Scandinavian Journal of Public Health·Axel SkyttheKaare Christensen
Sep 6, 2011·Nature Methods·Christoph LippertDavid Heckerman
Jan 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Or ZukEric S Lander
Jan 27, 2012·PloS One·Paola SebastianiThomas T Perls
Jul 19, 2012·Journal of Community Genetics·Vigdis StefansdottirJon J Jonsson
Jul 21, 2012·American Journal of Epidemiology·Mikael RostilaIchiro Kawachi
Oct 17, 2012·PLoS Genetics·Chuong B DoNicholas Eriksson
Dec 12, 2012·Frontiers in Genetics·Paola Sebastiani, Thomas T Perls
Jan 19, 2013·Science·Melissa GymrekYaniv Erlich
Jan 19, 2013·Nature Reviews. Genetics·Albert Tenesa, Chris S Haley
Nov 28, 2013·Genome Biology·Razib Khan, David Mittelman
Feb 5, 2014·Nature Reviews. Genetics·Krishna R Veeramah, Michael F Hammer
Sep 10, 2014·Nature Reviews. Genetics·Wen-Hua WeiChris S Haley
Nov 19, 2014·Nature Reviews. Genetics·Doug Speed, David J Balding
Mar 26, 2015·Nature Genetics·Daniel F GudbjartssonKari Stefansson

❮ Previous
Next ❯

Citations

Jan 15, 2019·PLoS Genetics·Hussein Al-AsadiJohn Novembre
May 10, 2019·PLoS Genetics·Tal ShorOmer Weissbrod
Mar 27, 2018·Nature Reviews. Genetics·Grant Otto
Jun 28, 2019·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Peter M VisscherChris S Haley
Nov 7, 2019·Nature Reviews. Genetics·David MelzerLuigi Ferrucci
Feb 23, 2020·Proteomics·Ksenia S KudryashovaBrian K Kennedy
Sep 7, 2018·Nature·Linda PartridgeP Eline Slagboom
Oct 26, 2018·Circulation Research·Cristina GiulianiClaudio Franceschi
Feb 7, 2019·Heredity·Konrad RawlikAlbert Tenesa
Aug 16, 2019·Nature Communications·Joris DeelenJoanne M Murabito
Apr 14, 2018·Science·Alexandre A Lussier, Alon Keinan
Jun 15, 2018·Médecine sciences : M/S·Bertrand Jordan
Oct 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Wenyun ZuoShripad Tuljapurkar
Dec 6, 2018·International Journal of Environmental Research and Public Health·José Álvarez-GarcíaDiego Fernando García-Vélez
May 2, 2020·Biogerontology·Deisi L BragaMarcelo A Mori
Sep 27, 2018·Familial Cancer·V StefansdottirJ J Jonsson
Jan 9, 2019·Nature Communications·Niels van den BergP Eline Slagboom
Sep 6, 2019·G3 : Genes - Genomes - Genetics·Kevin M WrightJ Graham Ruby
Jul 18, 2020·Nature Communications·Paul R H J TimmersJoris Deelen
Jun 10, 2020·Journal of Mathematical Biology·Magnus Dehli Vigeland
Aug 11, 2020·Human Genetics·Gerard MuntanéElisabet Vilella
Nov 21, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Niccolo' TesiHenne Holstege
Mar 16, 2021·Journal of Public Economics·Timothy HallidayAshley Wong
Mar 23, 2021·Frontiers in Genetics·Ting XuGuo-Bo Chen
Feb 6, 2021·Rejuvenation Research·Borut PoljsakIrina Milisav
Jul 16, 2021·Mechanisms of Ageing and Development·Michel PoulainGiovanni M Pes
Jul 24, 2021·Molecular Biology and Evolution·Xavier FarréGerard Muntané
Jun 5, 2021·Bioinformatics·Xiayuan HuangScott J Hebbring
Aug 27, 2021·GeroScience·Ryan FrankumLorna W Harries

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved