Quantitative analysis of retinal layers' optical intensities on 3D optical coherence tomography for central retinal artery occlusion

Scientific Reports
Haoyu ChenMilan Sonka

Abstract

Optical coherence tomography (OCT) provides not only morphological information but also information about layer-specific optical intensities, which may represent the underlying tissue properties. The purpose of this study is to quantitatively investigate the optical intensity of each retinal layers in central retinal artery occlusion (CRAO). Twenty-nine CRAO cases at acute phase and 33 normal controls were included. Macula-centered 3D OCT images were segmented with a fully-automated Iowa Reference Algorithm into 10 layers. Layer-specific mean intensities were determined and compared between the patient and control groups using multiple regression analysis while adjusting for age and optical intensity of the entire region. The optical intensities were higher in CRAO than in controls in layers spanning from the retinal ganglion cell layer to outer plexiform layer (standardized beta = 0.657 to 0.777, all p < 0.001), possibly due to ischemia. Optical intensities were lower at the photoreceptor, retinal pigment epithelium (RPE), and choroid layers (standardized beta = -0.412 to -0.611, all p < 0.01), possibly due to shadowing effects. Among the intraretinal layers, the inner nuclear layer was identified as the best indicator of CRAO...Continue Reading

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Mar 31, 2017·Retina·Haoyu ChenXinjian Chen
May 2, 2017·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society· Jingyun Guo Xinjian Chen
Jul 19, 2016·Journal of Biomedical Optics·Ivica KoprivaXinjian Chen
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Aug 12, 2021·Scientific Reports·Ratheesh K MeleppatRobert J Zawadzki

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