PMID: 11606886Oct 19, 2001Paper

Quantitative analysis of striatal dopamine D2 receptors with 123 I-iodolisuride SPECT in degenerative extrapyramidal diseases

Nuclear Medicine Communications
C PrunierJ L Baulieu

Abstract

123I-Iodolisuride has high specific affinity for binding on dopamine D2 receptors in the striatum and has been used in a few single photon emission computed tomography (SPECT) studies of extrapyramidal disorders. The diagnosis of Parkinson's disease (PD) is very difficult in the first 5 years of evolution, with 15-25% false positive diagnoses. The aim of this study was therefore to determine the value of iodolisuride SPECT in discriminating Parkinson's from the most frequent Parkinson-plus syndromes (PPS). Seventeen patients with an extrapyramidal syndrome had a SPECT examination 1 h after injection of 180-185 MBq of 123I-iodolisuride. They were followed under dopaminergic treatment for at least 2 years. After 2 years, they were separated in two groups according to specific clinical criteria and sensitivity to dopaminergic treatment: nine patients had PD (age = 59.8+/-8.8 years; Hoehn and Yahr = 1.8+/-0.7; evolution = 4.3+/-3 years) and eight had PPS (age = 71.6+/-7.3 years; Hoehn and Yahr = 2.9+/-2.0; evolution = 4.1+/-1.5 years). The binding potential of iodolisuride in the striatum was assessed by considering the striatum (S)/occipital lobe (O) ratio at the pseudo-equilibrium 1 h after injection. The S/O ratio was statistica...Continue Reading

References

Oct 1, 1994·Nuclear Medicine Communications·J SchwarzK L Leenders
Jan 1, 1994·Pharmacology & Therapeutics·D M Jackson, A Westlind-Danielsson
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J LoganP King
Apr 1, 1994·Acta Psychiatrica Scandinavica·S RobinsonJ Rapaport
Sep 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·J B SchulzJ Dichgans
Aug 1, 1993·Annals of Neurology·A ChurchyardG Paxinos
Mar 1, 1993·Journal of the Neurological Sciences·D J Brooks
Dec 17, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·J SchwarzW H Oertel

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Citations

Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·Francis G Blankenberg, H William Strauss
Nov 15, 2005·Journal of Neural Transmission·R CiliaA Antonini
Aug 4, 2011·Brain : a Journal of Neurology·Jeffrey L CummingsPaul Kemp
Sep 4, 2007·BMC Neurology·Annemarie M M VlaarWim E J Weber
Nov 12, 2014·Nature Reviews. Neurology·Marios Politis
Oct 3, 2003·Journal of Cellular Biochemistry·Francis G Blankenberg
Mar 6, 2018·Neurology India·Madhavi TripathiChandrasekhar Bal
Dec 18, 2008·Expert Review of Neurotherapeutics·Angelo Antonini, Ioannis U Isaias
Jan 4, 2020·Oncology Letters·Gang ChenHongxia Chen
Feb 24, 2004·Molecular Pharmacology·R A BakkerR Leurs
May 7, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Valtteri KaasinenAngelo Antonini

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