Quantitative analysis of substance P-immunoreactive boutons on physiologically characterized dorsal horn neurons in the cat lumbar spinal cord

The Journal of Comparative Neurology
W MaA C Cuello

Abstract

A quantitative analysis of substance P (SP)-immunoreactive (IR) terminals contacting physiologically characterized dorsal horn neurons was performed. Three types of neuron were studied: nociceptive specific (NS) from lamina I (n = 3), wide dynamic range (WDR) from laminae II-IV (n = 3), and nonnociceptive (NN) from lamina IV (n = 3). The nociceptive response of focus was a slow, prolonged depolarization to noxious stimuli, because this response was previously shown to be blocked by selective neurokinin-1 (NK-1) receptor antagonists. Ultrastructural immunocytochemistry was used to quantify the relative number of SP-IR boutons apposed to the intracellularly labeled cell per unit of length (density). Densities of the total population (SP immunoreactive+nonimmunoreactive) of apposed boutons were similar in all three regions (cell body, proximal and distal dendrites) for the three functional types of neuron. NS neurons received a significantly higher density of appositions from SP-IR boutons than NN cells in all three regions. However, compared to WDR cells, NS cells possessed a significantly higher density of appositions from SP-IR boutons only in the cell body and proximal dendrites. WDR cells had a higher density of appositions f...Continue Reading

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Citations

Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·A L McLeodA Ribeiro-da-Silva
Mar 20, 2009·The Journal of Comparative Neurology·L AlmarestaniA Ribeiro-da-Silva
Oct 14, 2009·The Journal of Comparative Neurology·Matilde Cordero-ErausquinYves De Koninck
Nov 23, 2012·The Journal of Comparative Neurology·Abeer W Saeed, Alfredo Ribeiro-da-Silva
Feb 13, 1999·Progress in Neurobiology·M J Millan

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