Quantitative analysis of the color change after iodine staining for diagnosing esophageal high-grade intraepithelial neoplasia and invasive cancer

Gastrointestinal Endoscopy
Ryu IshiharaShingo Ishiguro

Abstract

Despite its high sensitivity for detecting esophageal cancer, chromoendoscopy with iodine staining has low specificity and requires many biopsy specimens, which is undesirable. Dramatic color change after iodine staining (initially whitish yellow and then pink 2 to 3 minutes later) has come to be recognized as the pink-color sign in cancerous lesions. The aim of the present study was to verify the accuracy of the pink-color sign for diagnosing esophageal squamous neoplasms by a quantitative analysis. A quantitative analysis of endoscopic images was performed by using prospectively pooled data. A cancer referral center. From December 2003 to September 2005, consecutive patients who underwent a procedure by an experienced endoscopist and had iodine-unstained lesions measuring 5 to 20 mm in diameter without obvious protrusions or ulcers were prospectively enrolled. The diagnostic ability of the quantitative assessment of the color change at 2 minutes after iodine staining (late phase) was investigated by using a receiver operating characteristic analysis. A total of 45 iodine-unstained lesions in 32 patients were included in the study. Among these, 22 of 23 pink-color-positive lesions were diagnosed as high-grade intraepithelial n...Continue Reading

Citations

Mar 26, 2010·Clinical Oral Investigations·Pelin GüneriHayal Boyacioğlu
Jul 28, 2010·Journal of Gastroenterology and Hepatology·Ryu IshiharaShingo Ishiguro
Jul 26, 2013·World Journal of Gastroenterology : WJG·Ryu IshiharaShingo Ishiguro
Jan 13, 2016·Leukemia & Lymphoma·Colin D GodwinRoland B Walter
Feb 15, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Manabu Muto
Jan 9, 2015·The American Journal of Gastroenterology·Yasuaki NagamiTetsuo Arakawa
Dec 28, 2018·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Jia-Yao ZhengWei Liang
Oct 31, 2018·Journal of Digestive Diseases·Yuan Yuan LiHeng Jin Dong
Sep 30, 2020·Current Oncology Reports·Charlotte Van LierdeVincent Vander Poorten
Jan 26, 2013·Revista do Colégio Brasileiro de Cirurgiões·Vitor ArantesTakashi Toyonaga
May 31, 2021·Esophagus : Official Journal of the Japan Esophageal Society·Mitsuhiro KonoYasuhiro Fujiwara

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