Quantitative analysis of the compound muscle action potential in early acute inflammatory demyelinating polyneuropathy

Electroencephalography and Clinical Neurophysiology
P CloustonD Cros

Abstract

We quantitated the size and configuration of compound muscle action potentials (CMAPs) in 266 nerves (66 median, 67 ulnar, 71 tibial and 62 peroneal) of 72 patients with acute inflammatory demyelinating polyneuropathy (AIDP) initially studied within 19 days of symptom onset. Results were compared with criteria for CMAP abnormalities, including criteria for abnormal negative peak duration and desynchronisation, derived from a control population of 50 median, ulnar, tibial and peroneal nerves. Other motor conduction abnormalities including minimal F response latency were also examined. We also analysed patterns of CMAP abnormality, peak disability and outcome for AIDP patients who had at least 3 motor nerves evaluated at first electrophysiologic study. Amongst AIDP nerves, low amplitude of the distal CMAP, usually with prolonged distal latency, was much more common than an abnormal fall in CMAP amplitude between stimulus sites. Using our CMAP criteria more than half of these low amplitude distal responses showed prolonged negative peak duration of desynchronisation or both, consistent with demyelination. Of the 47 AIDP patients who had 3 or more nerves initially studied, 37 (78.7%) had at least 1 motor nerve with a distal CMAP sh...Continue Reading

References

Oct 7, 1978·Lancet·R A HughesJ M Pierce
Jan 1, 1979·Muscle & Nerve·C P Panayiotopoulos
Oct 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·G K Harvey, J D Pollard
Jun 1, 1991·Brain : a Journal of Neurology·M HonavarJ B Winer
Jan 1, 1990·Annals of Neurology·A K Asbury, D R Cornblath
Sep 21, 1985·Lancet·K R Mills, N M Murray
Apr 1, 1988·Brain : a Journal of Neurology·F G van der MechéA Kievit
Apr 1, 1988·Annals of Neurology·D R CornblathS A Quaskey
Jul 1, 1988·Muscle & Nerve·R G MillerJ W Albers
Dec 1, 1986·Brain : a Journal of Neurology·T E FeasbyD W Zochodne
Mar 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·T E FeasbyA F Hahn
Feb 1, 1980·Journal of Neurology, Neurosurgery, and Psychiatry·T LachmanR R Young
Jan 1, 1981·Annals of Neurology·J G McLeod
Mar 1, 1984·Brain : a Journal of Neurology·W F Brown, T E Feasby
Aug 1, 1994·Electroencephalography and Clinical Neurophysiology·L KiersD Cros

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Citations

Jan 22, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M-C DurandT Sharshar
Jan 25, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·S KuwabaraN Yuki
Sep 18, 2009·Muscle & Nerve·Fabio A Barroso, Macarena I de la Fuente
Sep 17, 2013·Muscle & Nerve·Hessel Franssen, Dirk C G Straver
Jun 23, 2011·Journal of the Peripheral Nervous System : JPNS·Maria A AlbertíCarlos Casasnovas
Sep 8, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Steve VucicDidier Cros
Aug 2, 2014·Journal of Neurology·Takafumi HosokawaToshiaki Hanafusa
Apr 16, 2014·The International Journal of Neuroscience·Sambit DashPragna Rao
Jul 24, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Satoshi Kuwabara
Jun 10, 2016·Journal of Neurology·Takafumi HosokawaToshiaki Hanafusa
May 26, 1999·American Journal of Physical Medicine & Rehabilitation·R L Harmon, A H Naylor
May 12, 2006·Muscle & Nerve·J Gert van Dijk
Apr 1, 2019·Acta Neurologica Scandinavica·María J SedanoJosé Berciano
Mar 19, 2008·Expert Review of Neurotherapeutics·H Franssen
Jun 6, 2009·Expert Review of Neurotherapeutics·Antonino Uncini, Nobuhiro Yuki
Mar 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·J G McLeod
May 10, 2005·Muscle & Nerve·Amer Al-ShekhleeBashar Katirji

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