Quantitative analysis of the epithelial lining architecture in radicular cysts and odontogenic keratocysts

Head & Face Medicine
Gabriel Landini

Abstract

This paper describes a quantitative analysis of the cyst lining architecture in radicular cysts (of inflammatory aetiology) and odontogenic keratocysts (thought to be developmental or neoplastic) including its 2 counterparts: solitary and associated with the Basal Cell Naevus Syndrome (BCNS). Epithelial linings from 150 images (from 9 radicular cysts, 13 solitary keratocysts and 8 BCNS keratocysts) were segmented into theoretical cells using a semi-automated partition based on the intensity of the haematoxylin stain which defined exclusive areas relative to each detected nucleus. Various morphometrical parameters were extracted from these "cells" and epithelial layer membership was computed using a systematic clustering routine. Statistically significant differences were observed across the 3 cyst types both at the morphological and architectural levels of the lining. Case-wise discrimination between radicular cysts and keratocyst was highly accurate (with an error of just 3.3%). However, the odontogenic keratocyst subtypes could not be reliably separated into the original classes, achieving discrimination rates slightly above random allocations (60%). The methodology presented is able to provide new measures of epithelial arch...Continue Reading

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Citations

Dec 7, 2007·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Vesna ZivkovićMiljan Krstić
Dec 24, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Chiung-Chyi ShenBai-Shuan Liu
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Oct 7, 2011·Journal of Microscopy·M EramianT Daley
Mar 25, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Roseane Carvalho VasconcelosLélia Batista de Souza
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Jan 29, 2011·Journal of Dental Research·T-J Li
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May 10, 2019·Clinical Oral Investigations·Juliana Campos PinheiroPedro Paulo de Andrade Santos
Nov 12, 2016·Journal of Maxillofacial and Oral Surgery·Ashish GuptaSneha D Sharma
Oct 15, 2020·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Reetoja NagRaunak Kumar Das
Dec 20, 2016·Computers in Biology and Medicine·Joao B FlorindoGabriel Landini
Mar 1, 2011·Mathematical Biosciences·A Groh, M Wagner

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Methods Mentioned

BETA
light microscopy

Software Mentioned

SPSS
Optimas
ImageJ

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