Quantitative Analysis of Three Distinct Retinal Capillary Plexuses in Healthy Eyes Using Optical Coherence Tomography Angiography

Investigative Ophthalmology & Visual Science
Sean GarrityDavid Sarraf

Abstract

To identify and quantify the three distinct retinal capillary plexuses and the foveal avascular zone (FAZ) in healthy subjects according to age using optical coherence tomography angiography (OCTA) with novel projection artifact removal (PAR) software and improved segmentation. All eyes in this cross-sectional study underwent OCTA imaging using RTVue XR Avanti with novel PAR AngioVue software. OCTA scans were analyzed and the three main parafoveal retinal capillary plexuses were segmented and vessel density and FAZ area were calculated. A total of 152 normal eyes from 95 subjects (39 males, 56 females, mean age 42 ± 25 years) were included. The mean vessel density was 15.48 ± 2.04 mm-1 in the superficial retinal capillary plexus (SCP), 15.28 ± 1.82 mm-1 in the intermediate retinal capillary plexus (ICP), and 16.33 ± 2.32 mm-1 in the deep retinal capillary plexus (DCP) for 3 × 3-mm OCTA images. Analysis of 3 × 3-mm scans yielded a mean FAZ area of 0.270 ± 0.101 mm2. The average reduction in vessel density per year of age with 3 × 3-mm OCTA scans was 0.04 mm-1 (0.22%) in the SCP, 0.05 mm-1 (0.27%) in the ICP, and 0.06 mm-1 (0.30%) in the DCP. The average increase in FAZ area per year of age was 0.0015 mm2 (0.72%). Novel PAR softw...Continue Reading

Citations

Oct 4, 2018·Translational Vision Science & Technology·Rachel E LindermanJoseph Carroll
Jun 28, 2019·Investigative Ophthalmology & Visual Science·Karntida ChanwimolIrena Tsui
Jul 25, 2019·Investigative Ophthalmology & Visual Science·Ahmed M BataLeopold Schmetterer
Jan 22, 2020·Experimental Biology and Medicine·Xincheng YaoDevrim Toslak
Dec 14, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Taewoong UmYoung Hee Yoon
May 16, 2019·Retina·Carlo LaviaBénédicte Dupas
Jun 24, 2020·Investigative Ophthalmology & Visual Science·David Cordeiro SousaCarlos Marques-Neves
Sep 10, 2020·Investigative Ophthalmology & Visual Science·Jackson M ScharfDavid Sarraf
May 8, 2020·The British Journal of Ophthalmology·Caroline R BaumalK Bailey Freund
Sep 1, 2018·Investigative Ophthalmology & Visual Science·Mohammed AshrafAmani A Fawzi
Apr 16, 2019·Therapeutic Advances in Ophthalmology·Alex C Onishi, Amani A Fawzi
Jun 7, 2019·Translational Vision Science & Technology·Hirokazu IshiiKei Shinoda
Jun 30, 2019·Frontiers in Neuroscience·David Cordeiro SousaCarlos Marques-Neves
Mar 8, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Li SuSriniVas R Sadda
Aug 3, 2020·Ophthalmology and Therapy·Enrico BorrelliGiuseppe Querques
Oct 20, 2018·Ophthalmic Surgery, Lasers & Imaging Retina·Malvika AryaNadia K Waheed
Mar 15, 2019·Ophthalmology and Therapy·Enrico BorrelliGiuseppe Querques
Dec 21, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·N MihailovicM Alnawaiseh
Jun 12, 2019·Investigative Ophthalmology & Visual Science·Gregor Sebastian ReiterStefan Sacu
Jun 11, 2020·International Journal of Retina and Vitreous·Felix RommelMahdy Ranjbar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.