Quantitative analysis of transcranial and intraparenchymal light penetration in human cadaver brain tissue

Lasers in Surgery and Medicine
Clark E TedfordJuanita J Anders

Abstract

Photobiomodulation (PBM) also known as low-level light therapy has been used successfully for the treatment of injury and disease of the nervous system. The use of PBM to treat injury and diseases of the brain requires an in-depth understanding of light propagation through tissues including scalp, skull, meninges, and brain. This study investigated the light penetration gradients in the human cadaver brain using a Transcranial Laser System with a 30 mm diameter beam of 808 nm wavelength light. In addition, the wavelength-dependence of light scatter and absorbance in intraparenchymal brain tissue using 660, 808, and 940 nm wavelengths was investigated. Intact human cadaver heads (n = 8) were obtained for measurement of light propagation through the scalp/skull/meninges and into brain tissue. The cadaver heads were sectioned in either the transverse or mid-sagittal. The sectioned head was mounted into a cranial fixture with an 808 nm wavelength laser system illuminating the head from beneath with either pulsed-wave (PW) or continuous-wave (CW) laser light. A linear array of nine isotropic optical fibers on a 5 mm pitch was inserted into the brain tissue along the optical axis of the beam. Light collected from each fiber was deliv...Continue Reading

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Citations

Mar 12, 2016·Lasers in Medical Science·Mohammed A HadisWilliam M Palin
Aug 20, 2015·Advanced Healthcare Materials·Colleen N LoynachanPolina Anikeeva
Oct 19, 2016·BBA Clinical·Michael R Hamblin
Dec 22, 2016·Photomedicine and Laser Surgery·Connor Thunshelle, Michael R Hamblin
Feb 26, 2016·PloS One·Lihua SunKaisa M Hartikainen
Mar 23, 2018·Journal of Neurotrauma·Rinat O EsenalievMaria-Adelaide Micci
Mar 31, 2018·Journal of Clinical Psychopharmacology·Marco Antonio CaldieraroPaolo Cassano
Jun 6, 2017·Journal of Experimental Neuroscience·Cyril EleftheriouJose Fernando Maya-Vetencourt
Sep 15, 2017·Lasers in Surgery and Medicine·Clément DupontMaximilien Vermandel
Nov 14, 2017·Journal of Neuroscience Research·Michael R Hamblin
Oct 23, 2018·Photomedicine and Laser Surgery·Paolo CassanoDan V Iosifescu
Feb 20, 2019·Lasers in Surgery and Medicine·Burcu Tunc, Murat Gulsoy
Jul 25, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Reza Meynaghizadeh-ZargarSaeed Sadigh-Eteghad
Jul 4, 2019·Current Allergy and Asthma Reports·Victoria A WickenheisserTeresa Kathleen Tarrant
Sep 20, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Piero MannuPaolo Cassano
Mar 3, 2020·Journal of Drug Targeting·Siamak AlizadehYadollah Omidi
Jun 6, 2017·Journal of Optics·Madison Hennessy, Michael R Hamblin
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Sep 19, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Piero MannuPaolo Cassano
Feb 12, 2017·Photomedicine and Laser Surgery·Dionyssios MintzopoulosMarc J Kaufman
Oct 17, 2017·Frontiers in Psychiatry·Theodore A Henderson, Larry D Morries
May 11, 2018·BMC Neuroscience·Oksana PolesskayaMax Myakishev-Rempel
May 6, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Juanita J AndersRaymond J Lanzafame
Aug 29, 2019·Biomedical Engineering Letters·Jae-Hun LeeMin Young Lee
Oct 28, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Ana Maria Costa CarneiroRenato Amaro Zângaro
Mar 8, 2020·Lasers in Medical Science·Flávio Klinpovous KerppersIvo Ilvan Kerppers
Oct 28, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Paolo CassanoDan V Iosifescu

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