Quantitative analysis of transforming growth factor beta 1 mRNA in patients with alcoholic liver disease

World Journal of Gastroenterology : WJG
Wei-Xing ChenFeng Chen

Abstract

To investigate the expression of the transforming growth factor beta 1(TGF-beta 1) mRNA in different stages of alcoholic liver disease (ALD) and its clinical value. One hundred and seven male alcoholics were grouped by clinical findings into four groups: alcohol abusers without liver impairment (n =22), alcoholic steatosis (n =30); alcoholic hepatitis (n=31); and alcoholic cirrhosis(n=24). Using peripheral blood mononuclear cells (PBMC) as samples the gene expression of TGF-beta 1 was examined quantitatively by reverse transcription polymerase chain reaction (RT-PCR) and dot blot. There are 34 healthy subjects served as control. The expression of TGF-beta 1 from all ALD patients was significantly greater than that in controls (1.320 +/- 1.162 vs 0.808 +/- 0.276, P<0.001). The differences of the expressions were significant between the patients from each groups (alcoholic steatosis, alcoholic hepatitis and alcoholic cirrhosis) and the controls (1.168 +/- 0.852, 1.462 +/- 1.657, 1.329 +/- 0.610 vs 0.808 +/- 0.276, P<0.050). No significant differences of TGF -beta 1 mRNA expression were observed between alcohol abusers without liver impairment and controls. The expressions in patients with alcoholic hepatitis and alcoholic cirrhos...Continue Reading

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Citations

Nov 20, 2002·World Journal of Gastroenterology : WJG·Min ZhengRong-Hua Liu
Mar 3, 2004·World Journal of Gastroenterology : WJG·Yu-Tong HeYong-Hong Xiao
Nov 8, 2003·World Journal of Gastroenterology : WJG·Jun TaoRong-Hua Liu
Mar 31, 2004·World Journal of Gastroenterology : WJG·Yan-Jun LuoLi Wang
Jan 20, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Xingjun LiuJames Q Yin
Sep 16, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Javier OliverJosé M Ladero
Oct 2, 2009·Journal of Korean Medical Science·Yong-Ku KimIhn-Geun Choi
Jan 30, 2016·European Journal of Clinical Investigation·Gianluigi GiannelliAranzazu Sanchez
Jan 21, 2018·Cell Death & Disease·Haristi GaitantziSteven Dooley
Dec 14, 2005·Alcoholism, Clinical and Experimental Research·M T Pritchard, L E Nagy
Oct 24, 2012·Journal of Biomedicine & Biotechnology·Atef M Al-Attar
Sep 22, 2007·Phytotherapy Research : PTR·Hsun-Lang FangWen-Chuan Lin
May 12, 2006·World Journal of Gastroenterology : WJG·Wen-Chuan LinBor-Chen Wang
Mar 13, 2003·World Journal of Gastroenterology : WJG·Yu-Kan Liu, Wei Shen
Apr 23, 2009·Reproduction, Fertility, and Development·Leanne J McGrathSarah A Robertson
Jun 3, 2005·The American Journal of Gastroenterology·Jaana LatvalaOnni Niemelä
Feb 17, 2006·World Journal of Gastroenterology : WJG·Wen-Chuan Lin, Wei-Lii Lin

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