Quantitative analysis on isolated organs of the autonomic blocking properties of indoramin hydrochloride (Wy 21901)

British Journal of Pharmacology
B J AlpsA B Wilson

Abstract

1. Indoramin is a competitive alpha-adrenoceptor blocking agent on the guinea-pig isolated vas deferens and aortic strip; the pA(2) value on the aorta is 7.4.2. Indoramin is devoid of beta-adrenoceptor blocking activity on the guinea-pig isolated trachea (10(-4)M) and the Langendorff preparation of the rabbit heart (10(-6)M). It also has no adrenergic neurone blocking action on the Finkleman preparation of the rabbit small intestine (10(-5)M).3. On the Langendorff preparation of the rabbit isolated heart, indoramin (above 10(-6)M) has cardio-inhibitory properties similar to those of propranolol.4. On the guinea-pig isolated ileum (10(-5)M) and trachea (10(-6)M), indoramin is devoid of anticholinergic activity, but has a potent antihistamine action which satisfies the criteria for competitive antagonism; the pA(2) value for this antagonism on the ileum is 8.2.5. Indoramin antagonizes 5-hydroxytryptamine on the rat isolated fundus and ileum; the pA(2) value for the antagonism on the ileum is 6.0.

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Citations

Dec 18, 1978·European Journal of Clinical Pharmacology·D L Clement
May 1, 1975·European Journal of Pharmacology·T Baum, A T Shropshire
Feb 1, 1974·British Journal of Clinical Pharmacology·R B Royds, J D Lockhart
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Sep 1, 1973·The Journal of Pharmacy and Pharmacology·S Rashid, B J Alps
Oct 1, 1978·The Journal of Pharmacy and Pharmacology·D R Algate, J F Waterfall

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