DOI: 10.1101/478164Nov 26, 2018Paper

Quantitative analysis reveals reciprocal regulations underlying recovery dynamics of thymocytes and thymic environment

BioRxiv : the Preprint Server for Biology
Kazumasa B KanekoTetsuya J Kobayashi

Abstract

Thymic crosstalk, a set of reciprocal regulations between thymocytes and thymic environment, is relevant for orchestrating the appropriate development of thymocytes as well as the recovery of the thymus from various exogenous insults. Nevertheless, the dynamic and regulatory aspects of the thymic crosstalk have not yet been clarified. In this work, we inferred the interactions shaping the thymic crosstalk and its resultant dynamics between the thymocytes and the thymic epithelial cells (TECs) by quantitative analysis and modelling of the recovery dynamics induced by irradiation. The analysis identified regulatory interactions consistent with the known molecular evidence and revealed their dynamic roles in the recovery process. Moreover, the analysis also predicted, and a subsequent experiment verified a new regulation of CD4+CD8+ double positive (DP) thymocytes, which temporarily increases their proliferation rate upon the decrease in their population size. Our model established the pivotal step towards a dynamic understanding of the thymic crosstalk as a regulatory network system.

Related Concepts

Environment
Thymus Gland
Thymic Carcinoma
Thymic Epithelial Cell
Shapes
Size
CD4+CD8+
Cell Proliferation
Research Study
Drug Interactions

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