Quantitative and functional defects of dendritic cells in classic Kaposi's sarcoma

Clinical Immunology : the Official Journal of the Clinical Immunology Society
S Della BellaM L Villa

Abstract

In this study, we investigated whether dendritic cells (DCs) are altered in classic Kaposi's sarcoma (cKS), a lympho-angioproliferative disorder associated with human herpesvirus-8 (HHV-8) infection. By direct analysis of peripheral blood DCs (PBDCs), we demonstrated that cKS patients have lower frequency of myeloid and plasmacytoid DCs than controls. This reduction was greater in patients with advanced stages of disease. PBDCs from cKS patients also showed up-regulated expression of the scavenger receptor CD91 and impaired IL-12 expression. PB monocytes that represent DC precursors in vivo and in vitro showed the same alterations; accordingly, DCs differentiated in vitro from cKS monocytes were similarly affected. The same alterations were induced by addition of cKS plasma during DC differentiation from control monocytes. These results indicate that PBDCs and their precursors are altered in cKS and suggest that soluble circulating factors participate in this process. The study may provide new insights into the pathogenesis of cKS.

References

Sep 18, 1997·The Journal of Experimental Medicine·I Fugier-VivierC Rabourdin-Combe
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Apr 16, 2002·Science·Polly Matzinger
Dec 17, 2002·International Archives of Allergy and Immunology·Megan K LevingsMaria Grazia Roncarolo
Jan 7, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Steven A MilesDavid T Scadden
Feb 4, 2003·Nature Reviews. Immunology·Giorgio Trinchieri
Sep 13, 2003·Journal of Virology·Patricia G Spear, Richard Longnecker
Dec 15, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hiroaki YanagimotoYasuo Kamiyama
Apr 2, 2005·Nature Reviews. Immunology·Jacques Banchereau, A Karolina Palucka
Jun 21, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Zheng ZhangFu-Sheng Wang

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Citations

Oct 7, 2008·Oncogene·N ChaputL Zitvogel
Jul 1, 2009·The Journal of Experimental Medicine·Wei CaoYong-Jun Liu
Mar 23, 2011·Pathology International·Pratistadevi K RamdialBhugwan Singh
Mar 28, 2008·The British Journal of Dermatology·L BrambillaL Tedeschi
May 25, 2012·The Journal of Investigative Dermatology·Monica CappellettiSilvia Della Bella
Dec 18, 2008·The Journal of General Virology·Heather R HenslerFrank J Jenkins
Sep 16, 2014·Frontiers in Microbiology·Diana M CampbellCharles R Rinaldo
Jul 4, 2016·Archives of Dermatological Research·Mirna KarouniOssama Abbas
Mar 16, 2017·The Journal of Investigative Dermatology·Francesca CalcaterraSilvia Della Bella
Jul 14, 2009·Experimental and Molecular Pathology·Liron PantanowitzBruce J Dezube
Dec 11, 2007·Journal of the American Academy of Dermatology·Noël Emile Célestin SchartzCéleste Lebbé
Jun 19, 2008·Cytometry. Part B, Clinical Cytometry·Stefania GiannelliSilvia Della Bella
May 1, 2007·Expert Review of Clinical Immunology·Silvia Della BellaMaria Luisa Villa
Sep 17, 2014·Expert Review of Clinical Immunology·Marco TucciFranco Silvestris
Mar 1, 2011·Clinical and Experimental Immunology·S Della BellaM L Villa
Dec 5, 2019·Brazilian Dental Journal·Cinthia Veronica Bardalez Lopez de CáceresFelipe Paiva Fonseca
Oct 25, 2020·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Claudia CarenzaSilvia Della Bella
Mar 16, 2011·Cancer Letters·Suzane Ramos da Silva, Deilson Elgui de Oliveira

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