PMID: 9558491Apr 29, 1998Paper

Quantitative and objective evaluation of wound debriding properties of collagenase and fibrinolysin/desoxyribonuclease in a necrotic ulcer animal model

Archives of Dermatological Research
J R MekkesW Westerhof

Abstract

Proteolytic enzymes have been used for wound debridement for many years. The two enzymes most widely used in Europe are fibrinolysin/desoxyribonuclease and collagenase. Despite their frequent use, very few placebo-controlled studies comparing the enzymes with vehiculum only, or with each other, are available. In a specially developed necrotic ulcer animal model, combined with a computer image analysis technique to measure necrotic and total wound surface areas quantitatively, we assessed the wound-cleansing properties of fibrinolysin/DNase oleogel, collagenase ointment, saline-soaked gauze control treatment, and new galenic formulations of collagenase, including placebos. The average relative area of necrotic tissue present in the wound after 1 week was 31% for collagenase ointment and 56% for fibrinolysin/DNAse oleogel (P = 0.0037). Collagenase gel was significantly (P = 0.0007) better in removing necrosis than placebo (gel only). Fibrinolysin/DNAse was not significantly more effective than the three placebo or control treatments (placebo film, placebo gel, saline-soaked gauzes). We conclude that collagenase is a suitable enzyme for wound debridement, but we were not able to detect clinical efficacy of fibrinolysin/DNAse in th...Continue Reading

Citations

Sep 21, 2013·Aesthetic Plastic Surgery·Sara CarellaMaria Giuseppina Onesti
Dec 31, 2003·Biomaterials·E MiddelkoopM M W Ulrich
Dec 16, 2009·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Lei Shi, Dennis Carson
Aug 24, 2011·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Lei ShiDennis Carson
Apr 28, 2007·Pediatric Dermatology·Omer ErdeveSaadet Arsan
Jun 22, 2006·The Veterinary Clinics of North America. Small Animal Practice·D J Krahwinkel, Harry W Boothe
Nov 12, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Lei ShiDuncan Aust
Jul 6, 2007·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Avi ShaiIts'hak Dinstein
Oct 31, 2012·International Wound Journal·Maria G OnestiNicolo Scuderi
Jul 1, 2015·BMC Complementary and Alternative Medicine·Jamila Alessandra PeriniDaniel Escorsim Machado
Mar 20, 2002·Advances in Skin & Wound Care·A SinghalM D Kerstein
Sep 23, 2010·Advances in Skin & Wound Care·Lei ShiDennis Carson
Sep 10, 2002·Nursing·Elizabeth A AyelloMorris D Kerstein
Nov 30, 2006·Advances in Skin & Wound Care·Carly KirshenR Gary Sibbald
Feb 18, 2017·European Annals of Otorhinolaryngology, Head and Neck Diseases·J R GandyB J F Wong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
E M SkrabutJ M McPherson
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
J R MekkesW Westerhof
Surgical Endoscopy
J C LantisS D Schwaitzberg
In Vitro Cellular & Developmental Biology. Animal
Pei-Ching KuoJan-Kan Chen
© 2022 Meta ULC. All rights reserved