Quantitative and qualitative analysis of proteins in fresh frozen plasma obtained from whole blood donations and prepared with two photochemical treatments

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
J CidRamon Pau Pla

Abstract

Thirty-six fresh frozen plasma (FFP) units obtained from whole blood donations were used for 12 replicate experiments. For each replicate experiment, three ABO-matched FFP units were pooled and divided into three units containing different volumes of identical plasma. One unit was used as control FFP, one unit was treated with methylene blue plus visible light and one unit was treated with amotosalen and UVA light. The overall coagulation factor levels were better maintained in untreated FFP than in photochemically treated plasma. However, treated-plasma by both photochemical methods maintained coagulation factor levels that met or exceeded the European Pharmacopeia requirements for therapeutic plasma.

References

Feb 13, 2001·Transfusion·V HornseyC Prowse
Jun 26, 2001·Transfusion Medicine·UNKNOWN Council of Europe Expert Committee in Blood Transfusion Study Group on Pathogen Inactivation of Labile Blood Components
Mar 29, 2002·British Journal of Haematology·Rebecca CardiganLorna Williamson
Aug 16, 2003·Transfusion·Lorna M WilliamsonChris V Prowse
Apr 2, 2005·British Journal of Haematology·Koichi KokameToshiyuki Miyata
Jul 21, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·François DepasseMeyer-Michel Samama
Sep 22, 2006·Clinical Medicine & Research·Bjarte G Solheim
Jun 16, 2007·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Joan CidRamon Pau Pla

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Citations

Oct 1, 2013·Transfusion Medicine Reviews·Miguel LozanoThomas H Müller
Aug 1, 2012·Transfusion·Robert C GosselinDouglas Taylor
May 16, 2012·Photochemistry and Photobiology·Xiaoying LiuYongming Zhu
Oct 10, 2013·Current Opinion in Hematology·Miguel Lozano, Joan Cid
Oct 8, 2020·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Tomasz WasilukPiotr Radziwon

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