Quantitative anti-F1 and anti-V IgG ELISAs as serological correlates of protection against plague in female Swiss Webster mice

Vaccine
S F LittleJ J Adamovicz

Abstract

A recombinant fusion protein composed of Yersinia pestis fraction 1 capsule (F1) and virulence-associated V antigen (V) (F1-V) has been developed as the next-generation vaccine against plague. In this study, female Swiss Webster mice received a single intramuscular vaccination with one of eight doses of the F1-V vaccine and exposed 4 weeks later to either Y. pestis CO92 or C12 organisms by the subcutaneous or aerosol routes of infection. Quantitative anti-F1 and anti-V immunoglobulin G (IgG) ELISAs were used to examine the relationship between survival outcome and antibody titers to F1 and V. Results suggested that each 1log(10) increase in week 4 quantitative anti-F1 and anti-V IgG ELISA titers were associated with a 1.7-fold (p=0.0051) and 2.5-fold (p=0.0054) increase in odds of survival, respectively, against either bubonic or pneumonic plague and may serve as serological correlates of protection.

References

Oct 1, 1979·The Journal of Infectious Diseases·J E WilliamsD C Cavanaugh
Mar 13, 1986·Journal of Immunological Methods·M J Lacy, E W Voss
Sep 1, 1972·The Journal of Infectious Diseases·R C WilliamsP G Quie
May 1, 1974·The Journal of Infectious Diseases·K F MeyerJ D Marshall
May 1, 1974·The Journal of Infectious Diseases·K F MeyerF R McCrumb
Dec 1, 1995·FEMS Immunology and Medical Microbiology·E D WilliamsonA Robinson
Oct 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A M FriedlanderK Davis
May 30, 1998·Microbial Pathogenesis·S WelkosS Tobery
Apr 21, 1999·Clinical and Experimental Immunology·E D WilliamsonR W Titball
Apr 25, 2000·Medical Microbiology and Immunology·A RoggenkampJ Heesemann
Oct 12, 2000·Vaccine·E D WilliamsonR W Titball
Feb 21, 2002·Infection and Immunity·Yidong DuAke Forsberg
Oct 23, 2002·The Journal of Experimental Medicine·Andreas SingJürgen Heesemann
Feb 26, 2005·Infection and Immunity·Alexander V PhilipovskiySusan C Straley
May 24, 2005·Infection and Immunity·E D WilliamsonM Irving
Jun 9, 2005·Protein Expression and Purification·Wieslaw SwietnickiJeremy Goodin
Jun 28, 2005·BMC Microbiology·Jyl S MatsonMatthew L Nilles
Jul 30, 2005·Science·Melanie M MarketonOlaf Schneewind
Mar 23, 2007·Clinical and Vaccine Immunology : CVI·J BashawS Welkos
Nov 21, 2007·Infection and Immunity·Stanislav FormanSusan C Straley
May 20, 2008·Biologicals : Journal of the International Association of Biological Standardization·S F LittleJ J Adamovicz
Feb 1, 1947·Proceedings of the Society for Experimental Biology and Medicine·E E BAKER, H SOMMER

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Citations

Jun 15, 2011·Applied Microbiology and Biotechnology·Jason A RosenzweigAshok K Chopra

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