PMID: 6407154Mar 1, 1983Paper

Quantitative aspects of metal ion content and toxicity in Drosophila

Toxicology
N T ChristieK B Jacobson

Abstract

As a basis for both a genetic and a biochemical approach to a study of metal ion effects, a method for quantitating the toxic response of Drosophila to metal ions was developed. The response to 13 metal ions has been examined, including several chemical groups from the periodic table: the IIb ions Zn2+, Cd2+, and Hg2+; the IIa ions, Be2+, Mg2+, Sr2+, and Ba2+; the transition elements, Ni2+, Cu2+, Co2+, and Mn2+: and trivalent ions, Y3+ and Cr3+. The standard test procedure provides estimates of the median lethal concentration (LC50) and the range of the tolerance distribution both of which are obtained by the method of probit transformation. Range is defined as the change in concentration between the LC2.5 and the LC97.5. Estimation of range as the measure of the limits of the tolerance distribution was utilized to measure variation in the response to metals with time. Genetic characterization of strains will require strains of flies without overlapping tolerance ranges. Although there was a general trend of increasing values of range with increasing LC50 values, the exceptions (e.g., Cr3+ and Be2+) indicated that several factors may be involved in determining the range of lethal responses. Elemental analyses have been performe...Continue Reading

References

Dec 1, 1979·Food and Cosmetics Toxicology·M A Hayes, H B Schiefer
Sep 15, 1981·Toxicology and Applied Pharmacology·K B JacobsonN T Christie
May 1, 1982·Toxicology and Applied Pharmacology·M W WilliamsE H Lee
Sep 3, 1954·Science·W H SHAW

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Citations

Jan 1, 1992·Archives of Environmental Contamination and Toxicology·L PosthumaN M Van Straalen
Jan 1, 1992·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·J M AkinsH V Aposhian
Jan 1, 1991·Toxicology·M W EnglandK B Jacobson
Feb 7, 2001·Toxicology·J Pourahmad, P J O'Brien
Jan 1, 1993·Environmental and Molecular Mutagenesis·Y W LeeN T Christie
Jan 1, 1986·Teratogenesis, Carcinogenesis, and Mutagenesis·J Magnusson, C Ramel
Sep 5, 2018·Biological Trace Element Research·Paula Tais Halmenschelager, João Batista Teixeira da Rocha

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