Quantitative assessment of abdominal aortic calcification and associations with lumbar intervertebral disc height loss: the Framingham Study.

The Spine Journal : Official Journal of the North American Spine Society
P SuriJ N Katz

Abstract

Vascular disease has been proposed as a risk factor for disc height loss (DHL). To examine the relationship between quantitative measures of abdominal aortic calcifications (AACs) as a marker of vascular disease, and DHL, on computed tomography (CT). Cross-sectional study in a community-based population. Four hundred thirty-five participants from the Framingham Heart Study. Quantitative AAC scores assessed by CT were grouped as tertiles of "no" (reference), "low," and "high" calcification. Disc height loss was evaluated on CT reformations using a four-grade scale. For analytic purposes, DHL was dichotomized as moderate DHL of at least one level at L2-S1 versus less than moderate or no DHL. We examined the association of AAC and DHL using logistic regression before and after adjusting for cardiovascular risk factors and before and after adjusting for age, sex, and body mass index (BMI). In crude analyses, low AAC (odds ratio [OR], 2.05 [1.27-3.30]; p=.003) and high AAC (OR, 2.24 [1.38-3.62]; p=.001) were strongly associated with DHL, when compared with the reference group of no AAC. Diabetes, hypercholesterolemia, hypertension, and smoking were not associated with DHL and did not attenuate the observed relationship between AAC a...Continue Reading

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Citations

Aug 9, 2015·Annals of Nuclear Medicine·Nadia WithofsRoland Hustinx
Nov 17, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Abolhassan ShakeriDaniel Fadaei Fouladi
Feb 28, 2018·Frontiers in Physiology·Sharmayne R E BradyBarbora de Courten
Jul 28, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michelle S YauElizabeth J Samelson
Nov 14, 2018·Archives of Osteoporosis·Jarred KaiserElise F Morgan

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