Quantitative assessment of atherosclerotic plaques on (18)F-FDG PET/MRI: comparison with a PET/CT hybrid system

European Journal of Nuclear Medicine and Molecular Imaging
Xiang LiMarcus Hacker

Abstract

PET with (18)F-FDG has the potential to assess vascular macrophage metabolism. (18)F-FDG is most often used in combination with contrast-enhanced CT to localize increased metabolism to specific arterial lesions. Novel (18)F-FDG PET/MRI hybrid imaging shows high potential for the combined evaluation of atherosclerotic plaques, due to the superior morphological conspicuity of plaque lesions. The purpose of this study was to evaluate the reliability and accuracy of (18)F-FDG PET/MRI uptake quantification compared to PET/CT as a reference standard in patients with carotid atherosclerotic plaques. The study group comprised 34 consecutive oncological patients with carotid plaques who underwent both PET/CT and PET/MRI with (18)F-FDG on the same day. The presence of atherosclerotic plaques was confirmed by 3 T MRI scans. Maximum standardized uptake values (SUVmax) for carotid plaque lesions and the average SUV of the blood pool within the adjacent internal jugular vein were determined and target-to-blood ratios (TBRs, plaque to blood pool) were calculated. Atherosclerotic lesions with maximum colocalized focal FDG uptake were assessed in each patient. SUVmax values of carotid plaque lesions were significantly lower on PET/MRI than on P...Continue Reading

References

Nov 4, 1998·Medical Physics·P E KinahanD Sashin
Dec 21, 2000·Current Atherosclerosis Reports·G K Hansson
Nov 3, 2001·Stroke; a Journal of Cerebral Circulation·U G Schulz, P M Rothwell
Apr 30, 2003·Circulation·Ward CasscellsJames T Willerson
Jan 1, 1994·IEEE Transactions on Medical Imaging·H M Hudson, R S Larkin
Dec 24, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Matthias HofmannThomas Beyer
May 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Leon J MenezesAshley M Groves
Oct 8, 2009·Circulation. Cardiovascular Imaging·Albert J SinusasRobert J Gropler
Oct 8, 2009·Circulation. Cardiovascular Imaging·Matthias NahrendorfAlbert J Sinusas
Jun 2, 2010·Journal of the American College of Cardiology·James H F RuddAhmed A Tawakol
Jun 18, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Aloke V FinnRenu Virmani
Apr 27, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alexander DrzezgaMarkus Schwaiger
Nov 28, 2012·Seminars in Nuclear Medicine·Ilja BezrukovBernd J Pichler
Nov 28, 2012·Magma·Gudrun WagenknechtHans Herzog
Feb 14, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christoph RischplerMarkus Schwaiger
Aug 28, 2013·The International Journal of Cardiovascular Imaging·Frederik F StroblTobias Saam
Mar 19, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Björn A BlombergPoul F Høilund-Carlsen
Apr 23, 2015·The International Journal of Cardiovascular Imaging·Holger HetterichTobias Saam

❮ Previous
Next ❯

Citations

Aug 19, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·D L BaileyT Beyer
Sep 30, 2016·Current Cardiovascular Imaging Reports·Ljubica MandicMariann Gyöngyösi
Apr 7, 2017·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·David GrosharLiran Domachevsky
Apr 1, 2017·Circulation. Cardiovascular Imaging·Katrien Vandoorne, Matthias Nahrendorf
Apr 3, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Claudia CalcagnoZahi A Fayad
Apr 3, 2020·The British Journal of Radiology·Nicholas R EvansJames Hf Rudd
Feb 9, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jacobo Cal-GonzalezThomas Beyer
Dec 7, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kjersti JohnsrudMona-Elisabeth Revheim
Sep 22, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Xiang LiAlexander R Haug
Apr 21, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Xiang LiMarcus Hacker
Jul 23, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ivo RauschJacobo Cal-González
Apr 13, 2017·Current Cardiology Reports·Peter J BergquistJean Jeudy
May 23, 2018·Angiology·Mattia CattaneoAugusto Gallino
Nov 5, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ahmed HaiderMichael Fiechter
Oct 28, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Malte KircherXiang Li

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.