Quantitative assessment of bronchial wall attenuation with thin-section CT: An indicator of airflow limitation in chronic obstructive pulmonary disease

AJR. American Journal of Roentgenology
Tsuneo YamashiroGeorge R Washko

Abstract

The purpose of this study was to evaluate the relation between bronchial wall attenuation on thin-section CT images and airflow limitation in persons with chronic obstructive pulmonary disease. One hundred fourteen subjects (65 men, 49 women; age range, 56-74 years) enrolled in the National Lung Screening Trial underwent chest CT and prebronchodilation spirometry at a single institution. At CT, mean peak wall attenuation, wall area percentage, and luminal area were measured in the third, fourth, and fifth generations of the right B(1) and B(10) segmental bronchi. Correlations with forced expiratory volume in the first second of expiration (FEV(1)) expressed as percentage of predicted value were evaluated with Spearman's rank correlation test. The peak wall attenuation of each generation of segmental bronchi correlated significantly with FEV(1) as percentage of predicted value (B(1) third, r = -0.323, p = 0.0005; B(1) fourth, r = -0.406, p < 0.0001; B(1) fifth, r = -0.478, p < 0.0001; B(10) third, r = -0.268, p = 0.004; B(10) fourth, r = -0.476, p < 0.0001; B(10) fifth, r = -0.548, p < 0.0001). The correlation coefficients were higher in peripheral airway generations. Wall area percentage and luminal area had similar significant...Continue Reading

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Citations

Oct 2, 2012·Respiratory Investigation·Nguyen Van ThoYasutaka Nakano
Sep 24, 2014·AJR. American Journal of Roentgenology·Xueqian XieHarry J M Groen
Sep 21, 2012·Radiology·Maxime HackxPierre Alain Gevenois
Nov 26, 2013·Radiologic Clinics of North America·Diana E LitmanovichAlexander A Bankier
Nov 29, 2016·Chest·Alejandro A DiazRaul San Jose Estepar
May 28, 2016·The European Respiratory Journal·Kristoffer Ostridge, Tom M A Wilkinson
Oct 20, 2011·Journal of Thoracic Imaging·Hans-Ulrich KauczorJulia Ley-Zaporozhan
Feb 20, 2016·Experimental and Therapeutic Medicine·Ting ChengShaoguang Huang
Apr 30, 2020·Respiration; International Review of Thoracic Diseases·Noriyuki OhkuraRie Tanaka

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