Quantitative assessment of cerebellar ataxia, through automated limb functional tests

Journal of Neuroengineering and Rehabilitation
Ragil KrishnaDavid J Szmulewicz

Abstract

Cerebellar damage can often result in disabilities affecting the peripheral regions of the body. These include poor and inaccurate coordination, tremors and irregular movements that often manifest as disorders associated with balance, gait and speech. The severity assessment of Cerebellar ataxia (CA) is determined by expert opinion and is likely to be subjective in nature. This paper investigates automated versions of three commonly used tests: Finger to Nose test (FNT), test for upper limb Dysdiadochokinesia Test (DDK) and Heel to Shin Test (HST), in evaluating disability due to CA. Limb movements associated with these tests are measured using Inertial Measurement Units (IMU) to capture the disability. Kinematic parameters such as acceleration, velocity and angle are considered in both time and frequency domain in three orthogonal axes to obtain relevant disability related information. The collective dominance in the data distributions of the underlying features were observed though the Principal Component Analysis (PCA). The dominant features were combined to substantiate the correlation with the expert clinical assessments through Linear Discriminant Analysis. Here, the Pearson correlation is used to examine the relationship...Continue Reading

References

Mar 1, 1991·Journal of Neurophysiology·J HoreH C Diener
Jul 1, 1996·Journal of Neurophysiology·A J BastianW T Thach
Feb 18, 2003·Archives of Physical Medicine and Rehabilitation·Peter G FeysPierre Ketelaer
Sep 15, 2004·Journal of Human Genetics·Hiroki TakahashiHidehiro Mizusawa
Sep 21, 2004·The Journal of Neuropsychiatry and Clinical Neurosciences·Jeremy D Schmahmann
Dec 15, 2004·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Cynthia GagnonJohanne Desrosiers
May 5, 2005·Experimental Neurology·Fay B HorakJohn G Nutt
Jun 14, 2006·Neurology·T Schmitz-HübschRoberto Fancellu
Feb 1, 2013·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Stepán ObdrzálekMichael Pavel
Feb 1, 2013·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Portia E TaylorTakeo Kanade
Nov 29, 2014·Journal of Neuroengineering and Rehabilitation·Oonagh M GigginsBrian Caulfield
Nov 27, 2015·Healthcare Technology Letters·Samitha W EkanayakePubudu N Pathirana
Jan 25, 2017·Journal of Neuroengineering and Rehabilitation·Marcos R M RodriguesMindy F Levin
Feb 12, 2017·Journal of Neuroengineering and Rehabilitation·Gudrun M JohanssonCharlotte K Häger

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Citations

Jun 13, 2020·Scientific Reports·Bipasha KashyapDavid Szmulewicz
Dec 4, 2020·Sensors·Yuichi MitsuiHitoshi Mochizuki
Dec 6, 2020·Journal of Neuroengineering and Rehabilitation·Ha TranDavid J Szmulewicz
Mar 3, 2021·The Cerebellum·Brandon OubreAnoopum S Gupta
Jul 25, 2021·The Cerebellum·Nergis C KhanAnoopum S Gupta
Aug 21, 2021·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Zeus T Dominguez-VegaNatasha M Maurits

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Methods Mentioned

BETA
feature extraction
PCA

Software Mentioned

BioKin

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