PMID: 8970876Dec 1, 1996Paper

Quantitative assessment of cerebral atrophy during and after treatment in children with acute lymphoblastic leukemia

Investigative Radiology
P PrassopoulosJ Panagiotou

Abstract

The authors evaluate quantitatively brain atrophy induced by central nervous system prophylaxis in children treated for acute lymphoblastic leukemia during and after therapy completion. Measurements of the width of the subarachnoid compartments were performed in 243 brain computed tomography (CT) examinations of 196 children examined during (125) and/or after (71) treatment for acute lymphoblastic leukemia without central nervous system involvement. Data were compared with normative data. RESULTS. Diffuse brain atrophy was observed in 74% and 65% of the CT examinations performed during and after cessation of treatment, respectively. The highest incidence of brain atrophy (78%) occurred during the administration of intrathecal chemotherapy. All children younger than 2 years of age exhibited brain atrophy. Brain atrophy is the principal CT finding in the majority of children treated for acute lymphoblastic leukemia and it can be attributed mainly to intrathecal chemotherapy. This finding can be observed long after therapy completion.

References

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Citations

Mar 14, 2003·Cancer Treatment Reviews·Jeffrey E Rubnitz, Ching-Hon Pui
Nov 1, 2003·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·M Moleski
Feb 5, 2010·The International Journal of Neuroscience·Omolola Mojisola AtalabiOlusegun Olusina Akinyinka
Jan 5, 2011·Annals of Neurology·Axel PetzoldRogier Hintzen
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ching-Hon Pui
Jul 15, 2004·Blood·Ching-Hon PuiUNKNOWN Total Therapy Study XIIIB at St Jude Children's Research Hospital

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