Quantitative assessment of hepatic fibrosis in chronic hepatitis B and C: T1 mapping on Gd-EOB-DTPA-enhanced liver magnetic resonance imaging

World Journal of Gastroenterology : WJG
Shen PanQi-Yong Guo

Abstract

To assess the accuracy of Look-Locker on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for staging liver fibrosis in chronic hepatitis B/C (CHB/C). We prospectively included 109 patients with CHB or CHC who underwent a 3.0-Tesla MRI examination, including T1-weighted and Look-Locker sequences for T1 mapping. Hepatocyte fractions (HeF) and relaxation time reduction rate (RE) were measured for staging liver fibrosis. A receiver operating characteristic analysis using the area under the receiver operating characteristic curve (AUC) was used to compare the diagnostic performance in predicting liver fibrosis between HeF and RE. A total of 73 patients had both pathological results and MRI information. The number of patients in each fibrosis stage was evaluated semiquantitatively according to the METAVIR scoring system: F0, n = 23 (31.5%); F1, n = 19 (26.0%); F2, n = 13 (17.8%); F3, n = 6 (8.2%), and F4, n = 12 (16.4%). HeF by EOB enhancement imaging was significantly correlated with fibrosis stage (r = -0.808, P < 0.05). AUC values for diagnosis of any (≥ F1), significant (≥ F2) or advanced (≥ F3) fibrosis, and cirrhosis (F4) using HeF were 0.837 (0.733-0.913), 0.8...Continue Reading

References

May 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A P Crawley, R M Henkelman
May 2, 1981·Lancet·F W SmithJ M Hutchison
May 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A M AisenS D Swanson
Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Feb 15, 2001·The New England Journal of Medicine·A A BravoS Chopra
Feb 4, 2005·The Journal of Clinical Investigation·Ramón Bataller, David A Brenner
Apr 22, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Mirko LeonhardtWerner Weitschies
Jul 16, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Wen LiXin Yu
Feb 24, 2011·Investigative Radiology·Takashi KatsubeTakamichi Murakami
Sep 29, 2011·Journal of Magnetic Resonance Imaging : JMRI·Marcelo Souto NacifDavid A Bluemke
Jan 27, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qing-Bing WangBei Zhang
Mar 7, 2012·Journal of Magnetic Resonance Imaging : JMRI·Kyung Ah KimKi Whang Kim
Apr 26, 2012·Journal of Magnetic Resonance Imaging : JMRI·Akihiro NishieHiroshi Honda
Nov 23, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khayriyyah Mohd HanafiahSteven T Wiersma
Sep 17, 2013·Journal of Hepatology·Rajarshi BanerjeeStefan Neubauer
Dec 19, 2013·Journal of Magnetic Resonance Imaging : JMRI·Michael J HouseTim G St Pierre
Jul 6, 2014·Journal of Magnetic Resonance Imaging : JMRI·Gilad LibermanDafna Ben Bashat
Aug 30, 2014·World Journal of Gastroenterology : WJG·Giada SebastianiKostas Pantopoulos
Oct 12, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghRichard L Ehman
Dec 22, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nezam H AfdhalJohn G McHutchison
Apr 14, 2015·BioMed Research International·Stefano PalmucciPietro Milone
Aug 13, 2015·Journal of Magnetic Resonance Imaging : JMRI·Zhiming LiXiaoming Yang
Oct 20, 2015·Scientific Reports·Niklas VerlohPhilipp Wiggermann
Jul 6, 2016·Frontiers in Pharmacology·Jun L ChinJohn D Ryan
Aug 17, 2016·Journal of Magnetic Resonance Imaging : JMRI·Krishna JuluruJonathan P Dyke
Dec 17, 2016·Journal of Magnetic Resonance Imaging : JMRI·Léonie PetitclercAn Tang
Feb 23, 2017·World Journal of Gastroenterology : WJG·Jin WangSudhakar K Venkatesh
Feb 27, 2017·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Ruo Fan ShengMeng Su Zeng
Apr 26, 2017·Endoscopic Ultrasound·Dongwook OhMyung-Hwan Kim
Aug 25, 2017·Endoscopic Ultrasound·Galab M HassanAnand V Sahai

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Citations

Apr 5, 2019·Journal of Clinical and Translational Hepatology·Patrick J Navin, Sudhakar K Venkatesh
Jun 19, 2019·Radiology·Gregor KörzdörferMathias Nittka
Dec 26, 2019·Abdominal Radiology·David H HoffmanKrishna Prasad Shanbhogue

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Methods Mentioned

BETA
biopsy
Look-Locker sequencing
biopsies
Look-Locker

Software Mentioned

SPSS
HepFract
Look
DICOM Viewer
MedCalc
HepFract progress

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