PMID: 6104412Apr 1, 1980

Quantitative assessment of placental transfer of fazadinium in obstetric anaesthesia

Acta Anaesthesiologica Scandinavica
J C BertrandJ M Desmonts


Fazadinium, 1 mg/kg, was administered to 16 women undergoing general anaesthesia for casearean section or vaginal delivery with forceps. Fazadinium serum levels were measured fluorimetrically in samples of maternal venous blood and umbilical arterial and venous blood obtained at the time of delivery. The umbilical to maternal ratio of venous fazadinium averaged 20% and was not influenced by the interval between induction and delivery. A lower concentration was found in the umbilical artery, and the arterial to venous cord blood concentration ratio was about 75% suggesting foetal drug uptake. In all cases, Apgar scores were normal at the fifth minute. It is concluded that there is a placental transfer of fazadinium; however, this transfer is limited and the risk of paralysis of the newborn appears unlikely after a single intubating dose of 1 mg/kg administered to the mother.


Jan 1, 1978·Acta Anaesthesiologica Scandinavica·P DuvaldestinJ M Desmonts
Aug 1, 1978·British Journal of Anaesthesia·P DuvaldestinJ M Desmonts
Jan 1, 1975·Anaesthesia·C E BloggJ A Bell
Mar 1, 1976·British Journal of Anaesthesia·I Kivalo, S Saarikoski
Apr 1, 1969·British Journal of Anaesthesia·J ThomasL E Mather


Jan 1, 1981·Pharmacology & Therapeutics·W J Waddell, C Marlowe
Jan 1, 1991·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S C JainK Ram

Related Concepts

General Anesthesia
Paracervical Block
Apgar Score
Postcesarean Section
Umbilical Cord Blood
Maternal-Fetal Exchange
Pyridinium Compounds

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