PMID: 3772412Oct 1, 1986Paper

Quantitative assessment of the effect of cyproheptadine on spastic paretic gait: a preliminary study

Journal of Neurology
M WainbergS Gauthier

Abstract

The effects of cyproheptadine were studied in two patients with spastic paresis. The study consisted of two phases: a control phase (no medication) and a cyproheptadine phase (8 mg t.i.d.). The effects were evaluated from electromyographic (EMG) and kinematic analysis of treadmill walking with a portion of body weight supported, and from clinical examination and subjective assessments. Episodes of spontaneous spasms and elicited clonus were reduced with cyproheptadine. Improvement in locomotor function was evidenced by a decreased cycle duration, more regular foot-floor contact, functional joint excursions, and increased walking speed. In addition, a tonic EMG activity pattern was replaced by phasic muscle activation in the proximal extensors especially. Selective proximal movements were unmasked (hip flexion) and certain functional activities (transfers, dressing) were facilitated. The results support the role of cyproheptadine as an antispastic medication. Study of the short-term and long-term benefits of cyproheptadine is continuing.

References

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Citations

Sep 1, 1989·Electroencephalography and Clinical Neurophysiology·J Fung, H Barbeau
Dec 12, 1995·European Journal of Pharmacology·M J Espey, J W Downie
Sep 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·M WainbergS Gauthier
Apr 14, 1999·Gait & Posture·S KhodadadehJ Patrick
Jul 25, 2006·The International Journal of Neuroscience·Reuven Sandyk
Jul 24, 2007·Gait & Posture·Nicolas TermozFrançois Prince
Nov 16, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Na Jin SeoDerek G Kamper
Feb 20, 1999·Archives of Physical Medicine and Rehabilitation·H BarbeauA Leroux
Oct 1, 1991·The Journal of the American Paraplegia Society·V R EdgertonR de Leon
Oct 1, 1993·The Journal of the American Paraplegia Society·S Rossignol, H Barbeau
Aug 1, 1987·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·P J BédardT DiPaolo
Nov 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J F YangH Barbeau

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