Quantitative assessment of tumor-associated tissue eosinophilia and mast cells in tumor proper and lymph nodes of oral squamous cell carcinoma

Journal of Oral and Maxillofacial Pathology : JOMFP
Shivani JainSankalp Sancheti

Abstract

Oral squamous cell carcinoma (OSCC) is the most common cancer of the oral cavity. Tumor stage, thickness, lymph node metastasis (LNM), extranodal spread, perineural invasion, tumor differentiation, mutations, human papillomavirus infection and tumor microenvironment are independent prognostic indicators of OSCC. However, clinically, among all factors, LNM is considered an important prognostic factor in OSCC as it not only determines the stage of disease but also the strongest independent factor which predicts recurrence of disease. Further research proves that there are several biologically important factors in tumor tissue and LNs which promote or defend LNM. While it is proposed that tumor-associated tissue eosinophils (TATE) and mast cells (MCs) have "immuno-protective" effect, this remains unproven and various researchers have conflicting opinion. The aim is to determine the presence of TATE and MCs in OSCC and to evaluate if any association exists between them and LNM. It is a comparative retrospective study between two groups including 35 OSCC cases positive and 35 negative for LNM. Quantification of cells was done by counting total number of cells in 10 high-power fields under ×40 objective lens using "zigzag" method and...Continue Reading

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Sep 28, 2021·International Journal of Dermatology·Daniel Elieh Ali Komi, Ahmad Jalili

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