Quantitative autoradiographic distribution of [3H]mazindol-labeled dopamine uptake sites in the brains of superoxide dismutase transgenic mice

Brain Research Bulletin
J L CadetC J Epstein

Abstract

Superoxide dismutase (SOD) is an important enzyme which is involved in the dismutation of the toxic radical, superoxide anion. The activity of CuZnSOD is increased in patients who suffer from Down's Syndrome, Alzheimer's disease, and in Parkinson's disease. In order to evaluate the contribution of this enzyme to the neuropathology of these neurodegenerative diseases, transgenic mice have been constructed which express the human CuZnSOD gene. As a first step towards exploring these issues, we have carried out an autoradiographic binding study of the distribution of the catecholaminergic uptake blocker mazindol in the brain of these transgenic mice and of their littermates. Desmethylimipramine (DMI)-insensitive [3H]mazindol binding sites which correspond to dopamine uptake sites were located in the striatum, the nucleus accumbens, the olfactory tubercle and in the substantia nigra. Within the striatum, there was a lateromedial gradient, with higher concentration of dopamine uptake sites being found laterally. These findings suggest that subregions of the basal ganglia may be more susceptible to the deleterious effects of dopaminotoxic drugs which are taken up into the dopaminergic neurons via these uptake sites. Saturation experi...Continue Reading

References

Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Jan 1, 1989·Free Radical Biology & Medicine·D Jamieson
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A M Graybiel, R Moratalla
May 1, 1988·The International Journal of Neuroscience·J L Cadet
Feb 20, 1987·Science·P H St George-HyslopD Drachman
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C J EpsteinY Groner
Jan 25, 1985·Science·P A Cerutti
Aug 1, 1985·Archives of Biochemistry and Biophysics·J Blum, I Fridovich
Jan 1, 1986·Annual Review of Physiology·W A Pryor
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E DancigerY Groner
Sep 1, 1986·Biological Psychiatry·O J ThienhausH B Bosmann
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·A W Girotti
Jan 1, 1980·Annual Review of Neuroscience·G Jonsson
Jan 1, 1982·Annals of the New York Academy of Sciences·P M Sinet
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·I Fridovich

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