Quantitative biology of hydrogen peroxide signaling

Redox Biology
Fernando Antunes, Paula Matos Brito

Abstract

Hydrogen peroxide (H2O2) controls signaling pathways in cells by oxidative modulation of the activity of redox sensitive proteins denominated redox switches. Here, quantitative biology concepts are applied to review how H2O2 fulfills a key role in information transmission. Equations described lay the foundation of H2O2 signaling, give new insights on H2O2 signaling mechanisms, and help to learn new information from common redox signaling experiments. A key characteristic of H2O2 signaling is that the ratio between reduction and oxidation of redox switches determines the range of H2O2 concentrations to which they respond. Thus, a redox switch with low H2O2-dependent oxidability and slow reduction rate responds to the same range of H2O2 concentrations as a redox switch with high H2O2-dependent oxidability, but that is rapidly reduced. Yet, in the first case the response time is slow while in the second case is rapid. H2O2 sensing and transmission of information can be done directly or by complex mechanisms in which oxidation is relayed between proteins before oxidizing the final regulatory redox target. In spite of being a very simple molecule, H2O2 has a key role in cellular signaling, with the reliability of the information tra...Continue Reading

References

Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Apr 1, 1995·Archives of Biochemistry and Biophysics·A G WieseK J Davies
Feb 20, 1995·Archives of Biochemistry and Biophysics·J M DaviesK J Davies
Jun 20, 2000·FEBS Letters·F Antunes, E Cadenas
Oct 3, 2000·The EMBO Journal·A DelaunayM B Toledano
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Zhong-Yin Zhang
Feb 28, 2002·Molecular Cell·Tzu-Ching MengNicholas K Tonks
Nov 20, 2002·Cell·Agnès DelaunayMichel B Toledano
Jun 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ana P VivancosElena Hidalgo
Nov 23, 2006·Chemical Research in Toxicology·Daniel F TrindadeOhara Augusto
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Virgínia de Oliveira-MarquesFernando Antunes
Apr 7, 2007·Journal of the American Chemical Society·Jason N LaButtiKent S Gates
Jun 12, 2008·Free Radical Biology & Medicine·Christine C Winterbourn, Mark B Hampton
Nov 13, 2008·Antioxidants & Redox Signaling·Nicolas BrandesUrsula Jakob
Dec 9, 2008·Archives of Biochemistry and Biophysics·Bruno MantaAna Denicola
Jan 7, 2010·Biochemistry·Henry Jay FormanFulvio Ursini
Feb 4, 2010·Antioxidants & Redox Signaling·Nnenna J AdimoraMelissa L Kemp
Oct 12, 2010·The Journal of Biological Chemistry·Eva-Maria HanschmannChristopher Horst Lillig
Jan 5, 2011·Antioxidants & Redox Signaling·Regina Brigelius-Flohé, Leopold Flohé
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dmitri E FomenkoVadim N Gladyshev
Mar 12, 2011·Chemical Research in Toxicology·Gerardo Ferrer-SuetaAna Denicola
Jun 3, 2011·Mathematical Biosciences and Engineering : MBE·Tamar Friedlander, Naamar Brenne
Sep 15, 2011·Journal of the American Chemical Society·Haiying ZhouKent S Gates
Dec 8, 2011·The Journal of Biological Chemistry·Sue Goo RheeSoo Han Bae
Aug 21, 2012·Free Radical Biology & Medicine·Reagan M JarvisElizabeth C Ledgerwood
Mar 15, 2013·Free Radical Biology & Medicine·Mirko C SobottaTobias P Dick
Apr 2, 2013·The Journal of Biological Chemistry·Alexander V PeskinChristine C Winterbourn
Jul 19, 2013·The Journal of Biological Chemistry·Young-Mi Go, Dean P Jones
Aug 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Markus DagnellArne Östman
Sep 12, 2013·Redox Biology·Virgínia Oliveira-MarquesLuísa Cyrne
Mar 19, 2014·Redox Biology·H Susana MarinhoFernando Antunes
Jul 1, 2014·The FEBS Journal·Ulla SchwertassekNicholas K Tonks
Aug 27, 2014·Free Radical Biology & Medicine·Ralf P BrandesKatrin Schröder
Oct 4, 2014·Free Radical Biology & Medicine·Christine C Winterbourn
Nov 18, 2014·Nature Chemical Biology·Mirko C SobottaTobias P Dick
Dec 3, 2014·Free Radical Biology & Medicine·P Andrew Karplus
Dec 3, 2014·Redox Biology·Beijing K Huang, Hadley D Sikes
Apr 22, 2015·Antioxidants & Redox Signaling·Dean P Jones, Helmut Sies
Jun 11, 2015·Antioxidants & Redox Signaling·Marcus CebulaElias S J Arnér

❮ Previous
Next ❯

Citations

Nov 9, 2017·Antioxidants & Redox Signaling·Christine C Winterbourn
Jan 13, 2018·Antioxidants & Redox Signaling·Luksana ChaiswingDaret K St Clair
Aug 16, 2017·Chembiochem : a European Journal of Chemical Biology·Safnas F AbdulSalamEdward J Merino
Dec 19, 2017·Nature Chemical Biology·Sarah StöckerTobias P Dick
Apr 20, 2019·Antioxidants·Martina JankůMarek Petřivalský
Apr 14, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alejandra MartínezLucía Piacenza
Jul 31, 2019·International Journal of Molecular Sciences·Celien LismontMarc Fransen
Aug 1, 2019·The New Phytologist·Daniela Elisabeth NordziekeAntonio Di Pietro
Feb 10, 2018·Current Medicinal Chemistry·Andrea SilvestriniAntonio Mancini
Nov 7, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Seon-Ae JeonJe-Yoel Cho
May 27, 2020·International Journal of Sports Medicine·Michalis G NikolaidisAntonios Matsakas
Sep 15, 2020·PLoS Computational Biology·Kassi T SteinHadley D Sikes
Jul 31, 2018·Oxidative Medicine and Cellular Longevity·Ryan J Mailloux
Mar 29, 2020·Biochemical Society Transactions·Clara Ortegón SalasManuela Gellert
Nov 23, 2018·Antioxidants·Daniela E Nordzieke, Iria Medraño-Fernandez
Sep 16, 2019·Free Radical Biology & Medicine·Alexander V PeskinChristine C Winterbourn
Oct 22, 2020·IScience·Eric VanArsdaleWilliam E Bentley
Apr 25, 2021·Redox Biology·Claudia Lennicke, Helena M Cochemé
Nov 8, 2018·International Journal of Biological Macromolecules·Yunes PanahiAli A Moosavi-Movahedi
Aug 28, 2018·Chemical Reviews·Saba ParvezYimon Aye
Aug 28, 2021·Cells·Don A DaviesBenedict C Albensi
Sep 4, 2021·IUBMB Life·Nikos V MargaritelisMichalis G Nikolaidis

❮ Previous
Next ❯

Software Mentioned

Maxima

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Agricultural and Food Chemistry
J W FinleyS C Witt
Current Opinion in Cell Biology
Colleen R Reczek, Navdeep S Chandel
International Journal of Molecular Sciences
Patrícia A Madureira, David M Waisman
© 2022 Meta ULC. All rights reserved