Quantitative CEST and MT at 1.5T for monitoring treatment response in glioblastoma: early and late tumor progression during chemoradiation.

Journal of Neuro-oncology
Rachel W ChanAngus Lau

Abstract

Quantitative MRI (qMRI) was performed using a 1.5T protocol that includes a novel chemical exchange saturation transfer/magnetization transfer (CEST/MT) approach. The purpose of this prospective study was to determine if qMRI metrics at baseline, at the 10th and 20th fraction during a 30 fraction/6 week standard chemoradiation (CRT) schedule, and at 1 month following treatment could be an early indicator of response for glioblastoma (GBM). The study included 51 newly diagnosed GBM patients. Four regions-of-interest (ROI) were analyzed: (i) the radiation defined clinical target volume (CTV), (ii) radiation defined gross tumor volume (GTV), (iii) enhancing-tumor regions, and (iv) FLAIR-hyperintense regions. Quantitative CEST, MT, T1 and T2 parameters were compared between those patients progressing within 6.9 months (early), and those progressing after CRT (late), using mixed modelling. Exploratory predictive modelling was performed to identify significant predictors of early progression using a multivariable LASSO model. Results were dependent on the specific tumor ROI analyzed and the imaging time point. The baseline CEST asymmetry within the CTV was significantly higher in the early progression cohort. Other significant predic...Continue Reading

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Citations

Feb 16, 2021·Frontiers in Oncology·Petra J van HoudtUulke A van der Heide
Jun 3, 2021·Cancers·Catherine CoolensFabio Ynoe de Moraes
Jul 20, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Rachel W ChanAngus Z Lau
Sep 7, 2021·Medical Physics·Nikolai J MickeviciusCarri K Glide-Hurst

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