PMID: 9432034Jan 31, 1998Paper

Quantitative characterization and potential function of membrane Fas/APO-1 (CD95) receptors on leukaemic cells from chronic B and T lymphoid leukaemias

British Journal of Haematology
S KamihiraN Kobayashi

Abstract

The expression and function of the Fas-receptor (Fas-R) were examined in chronic lymphocytic leukaemia (CLL), hairy cell leukaemia-variant (HCL-v) and adult T-cell leukaemia (ATL). The expression of Fas-R in freshly isolated leukaemic cells was qualitatively and quantitatively different between each disease; faint in B-CLL, moderate in HCL-v and strong in ATL. Both full-length and alternatively spliced truncated forms of Fas mRNA were detected even in CLL B cells with faint to negative Fas-R, and Fas mRNA was also shown to be capable of increasing in vitro expression, i.e. the message was functional. In contrast, Fas-R expression on ATL cells was heterogenous and usually intense with a mean density approximately 3-fold higher than that of normal T cells. Fas-R was confirmed to have the potential function for anti-Fas monoclonal antibody-mediated cell death in vitro in Fas-R+ ATL cells. The expression level of Fas-R on the cells was higher in chronic than acute ATL (10,360 v 6260 antibody-binding capacity per cell, mFasABC; P<0.05) and was inversely correlated with serum LDH activity, suggesting that the strong Fas-R accounts for the slow progression of chronic ATL and the negative Fas-R protects from Fas-mediated cell death. Th...Continue Reading

Citations

Oct 12, 2000·Hematological Oncology·D P Bentley, C J Pepper
Aug 1, 2000·Indian Journal of Clinical Biochemistry : IJCB·S KamihiraT Maeda
Sep 5, 2002·Biochemical and Biophysical Research Communications·Takahiro MaedaShimeru Kamihira
Jun 26, 2001·European Journal of Haematology·L M OsorioM Jondal
Aug 8, 1998·British Journal of Haematology·M IwanagaM Tomonaga
Apr 6, 1999·The Journal of Experimental Medicine·T MaedaS Kamihira
Oct 24, 2000·Leukemia & Lymphoma·E J Schattner
May 9, 2001·Leukemia & Lymphoma·S Kamihira, Y Yamada
Sep 27, 2005·Leukemia Research·Peter GreaneyMichel A Duchosal
Jul 16, 2010·Blood·Emanuela RosatiPierfrancesco Marconi
Jul 16, 2005·Pediatric Hematology and Oncology·Lale Olcay, Ahmet Koç
Aug 9, 2001·Reviews in Clinical and Experimental Hematology·F Caligaris-Cappio
Aug 7, 2001·Reviews in Clinical and Experimental Hematology·E OrsiniR Foa
Feb 13, 2003·European Journal of Haematology·Liat DruckerMichael Lishner

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