Quantitative characterizations of ultrashort echo (UTE) images for supporting air-bone separation in the head

Physics in Medicine and Biology
Shu-Hui HsuJames M Balter

Abstract

Accurate separation of air and bone is critical for creating synthetic CT from MRI to support Radiation Oncology workflow. This study compares two different ultrashort echo-time sequences in the separation of air from bone, and evaluates post-processing methods that correct intensity nonuniformity of images and account for intensity gradients at tissue boundaries to improve this discriminatory power. CT and MRI scans were acquired on 12 patients under an institution review board-approved prospective protocol. The two MRI sequences tested were ultra-short TE imaging using 3D radial acquisition (UTE), and using pointwise encoding time reduction with radial acquisition (PETRA). Gradient nonlinearity correction was applied to both MR image volumes after acquisition. MRI intensity nonuniformity was corrected by vendor-provided normalization methods, and then further corrected using the N4itk algorithm. To overcome the intensity-gradient at air-tissue boundaries, spatial dilations, from 0 to 4 mm, were applied to threshold-defined air regions from MR images. Receiver operating characteristic (ROC) analyses, by comparing predicted (defined by MR images) versus 'true' regions of air and bone (defined by CT images), were performed with ...Continue Reading

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Citations

Oct 16, 2015·International Journal of Radiation Oncology, Biology, Physics·Weili ZhengCarri K Glide-Hurst
Nov 20, 2015·International Journal of Radiation Oncology, Biology, Physics·Eric ParadisJames M Balter
Mar 1, 2017·International Journal of Radiation Oncology, Biology, Physics·Shangjie RenRuijiang Li
Mar 18, 2017·Physics in Medicine and Biology·Jeremy S BredfeldtJames M Balter
Aug 2, 2018·Abdominal Radiology·Albert T RohAndreas M Loening
Jan 25, 2020·Investigative Radiology·Junichi TokudaEhud J Schmidt
Feb 3, 2018·Physics in Medicine and Biology·Amir M OwrangiCarri K Glide-Hurst
May 12, 2016·Journal of Applied Clinical Medical Physics·Shupeng ChenDi Yan
Jun 15, 2017·Japanese Journal of Radiology·Ilamurugu ArivarasanVelayudham Ramasubramanian
May 8, 2019·Medical Physics·Kuan-Hao SuRaymond F Muzic
Jun 5, 2018·Practical Radiation Oncology·Eric D MorrisCarri Glide-Hurst
May 19, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Véronique FortierIves R Levesque
Jun 21, 2021·Seminars in Ultrasound, CT, and MR·Claudia F Kirsch, Mai-Lan Ho

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