Quantitative Comparison of Primary Cilia Marker Expression and Length in the Mouse Brain

Journal of Molecular Neuroscience : MN
Éva SiposPéter Ács

Abstract

Primary cilia are small, special cellular organelles that provide important sensory and signaling functions during the development of mammalian organs and coordination of postnatal cellular processes. Dysfunction of primary cilia are thought to be the main cause of ciliopathies, a group of genetic disorders characterized by overlapping developmental defects and prominent neurodevelopmental features. Although, disrupted cilia-linked signaling pathways have been implicated in the regulation of numerous neuronal functions, the precise role of primary cilia in the brain are still unknown. Importantly, studies of recent years have highlighted that different functions of primary cilia are reflected by their diverse morphology and unique signaling components localized in the ciliary membrane. In the present study, we conducted a comparative analysis of the expression pattern, distribution and length of adenylyl cyclase 3, somatostatin receptor 3, and ADP-ribosylation factor-like protein 13B expressing primary cilia in the mouse brain. We show that cilia of neurons and astrocytes display a well characterized distribution and ciliary marker arrangements. Moreover, quantitative comparison of their length, density and occurrence rate reve...Continue Reading

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Citations

May 10, 2020·EMBO Molecular Medicine·Angelisa FrascaNicoletta Landsberger
Sep 27, 2019·Scientific Reports·Ana Martin-HurtadoFrancesc R Garcia-Gonzalo
Aug 21, 2019·Human Molecular Genetics·Antonio Jesús Lara OrdónezSabine Hilfiker
Jan 11, 2020·Frontiers in Cellular Neuroscience·Rasem MustafaRosanna Parlato
Apr 27, 2019·Frontiers in Behavioral Neuroscience·Sonia NoceraCécile Viollet
Oct 12, 2018·Therapeutic Advances in Medical Oncology·María Álvarez-Satta, Ander Matheu

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Methods Mentioned

BETA
GTPases
GTPase

Software Mentioned

ISIS
Pannoramic Viewer
GraphPad
ImageJ
Fiji
GraphPad Prism

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