PMID: 8598369Mar 1, 1996Paper

Quantitative comparisons of continuous and pulsed low dose rate regimens in a model late-effect system

International Journal of Radiation Oncology, Biology, Physics
D J BrennerB V Worgul

Abstract

There is increasing interest and usage of pulsed low dose rate (PDR) brachytherapy, in which a single source is shuttled through the catheters of an implant, typically for about 10 min each hour. This study was designed to compare the late effects produced in various PDR regimens with those from the corresponding continuous low dose rate (CLDR) regimens. A model late-responding system was used, namely, cataract induction in the rat lens. This system has the advantage of being highly quantifiable. The rats eyes were exposed to a total dose of 15 Gy either continuously over 24 h, or with three different PDR regimens, all with the same total dose and overall time. We addressed three questions: (a) are late effects increased when a CLDR regimen is replaced with 10-min pulses repeated every hour? (b) Are late effects increased if hourly 10-min pulses are replaced with 10-min pulses repeated every 4 h? (c) Are late effects increased if 10-min pulses are replaced with 100-s pulses? We found that the four regimens under test, continuous, 10-min pulses each hour, 10-min pulses every 4 h, and 100-s pulses every hour, showed no significant differences in cataractogenic potential, as estimated with the Wilcoxon-Gehan test. Power tests indi...Continue Reading

References

Oct 1, 1975·Radiology·L L Schenken, R F Hagemann
Mar 1, 1992·The British Journal of Radiology·E J Hall, D J Brenner
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·J Fowler, M Mount
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·E ArmourA Martinez
Jan 1, 1991·International Journal of Radiation Oncology, Biology, Physics·D J Brenner, E J Hall
Jun 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·I Turesson, H D Thames
Jan 1, 1995·International Journal of Radiation Oncology, Biology, Physics·J F Fowler
Jan 1, 1995·International Journal of Radiation Oncology, Biology, Physics·D J BrennerR K Sachs
Jul 1, 1994·International Journal of Radiation Oncology, Biology, Physics·D J BrennerR K Sachs
Feb 1, 1994·International Journal of Radiation Oncology, Biology, Physics·K A MasonN Janjan
May 20, 1993·International Journal of Radiation Oncology, Biology, Physics·J F Fowler
Jan 1, 1997·International Journal of Radiation Oncology, Biology, Physics·C Z ChenD J Brenner

❮ Previous
Next ❯

Citations

May 23, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P SminiaD González González
Nov 19, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E J Hall, D J Brenner
Nov 19, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K HaustermansE van der Schueren
Nov 10, 2000·International Journal of Radiation Oncology, Biology, Physics·G P RaaphorstM Niedbala
Aug 23, 2001·International Journal of Radiation Oncology, Biology, Physics·L A PopA J van der Kogel
Jan 1, 1997·International Journal of Radiation Oncology, Biology, Physics·C Z ChenD J Brenner
Mar 1, 1997·International Journal of Radiation Oncology, Biology, Physics·J F Fowler, E F Van Limbergen
Jul 1, 1997·International Journal of Radiation Oncology, Biology, Physics·E P ArmourA Martinez
May 20, 1998·International Journal of Radiation Oncology, Biology, Physics·P SminiaD G González
Dec 30, 1998·International Journal of Radiation Oncology, Biology, Physics·P T JensenF Rosendal
Oct 24, 2012·Annals of the ICRP·N J Kleiman
Aug 6, 1998·The British Journal of Radiology·R G Dale, B Jones
Apr 25, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Antoine BrunaDidier Peiffert
Nov 2, 2007·Radiation Research·Norman J KleimanHoward B Lieberman
Mar 6, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·L KeilholzR Sauer
Feb 11, 2021·Gynecologic Oncology·Leonel Varela CagettiAgnès Tallet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.