Quantitative computed tomographic descriptors associate tumor shape complexity and intratumor heterogeneity with prognosis in lung adenocarcinoma.

PloS One
Olya GroveRobert J Gillies

Abstract

Two CT features were developed to quantitatively describe lung adenocarcinomas by scoring tumor shape complexity (feature 1: convexity) and intratumor density variation (feature 2: entropy ratio) in routinely obtained diagnostic CT scans. The developed quantitative features were analyzed in two independent cohorts (cohort 1: n = 61; cohort 2: n = 47) of patients diagnosed with primary lung adenocarcinoma, retrospectively curated to include imaging and clinical data. Preoperative chest CTs were segmented semi-automatically. Segmented tumor regions were further subdivided into core and boundary sub-regions, to quantify intensity variations across the tumor. Reproducibility of the features was evaluated in an independent test-retest dataset of 32 patients. The proposed metrics showed high degree of reproducibility in a repeated experiment (concordance, CCC≥0.897; dynamic range, DR≥0.92). Association with overall survival was evaluated by Cox proportional hazard regression, Kaplan-Meier survival curves, and the log-rank test. Both features were associated with overall survival (convexity: p = 0.008; entropy ratio: p = 0.04) in Cohort 1 but not in Cohort 2 (convexity: p = 0.7; entropy ratio: p = 0.8). In both cohorts, these features...Continue Reading

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Citations

Feb 21, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Marie-Charlotte DesseroitMathieu Hatt
Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
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Methods Mentioned

BETA
surgical resection
feature extraction
imaging
biopsies

Software Mentioned

Lung Tumor Analysis ( LuTA )
Definiens Developer XD©
MP
Stata
QuickHull
MATLAB

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