Quantitative Contrast-Enhanced Magnetic Resonance Lymphangiography of the Upper Limbs in Breast Cancer Related Lymphedema: An Exploratory Study

Lymphatic Research and Biology
Marco BorriPeter S Mortimer

Abstract

Contrast-Enhanced Magnetic Resonance Lymphangiography (CE-MRL) presents some limitations: (i) it does not quantify lymphatic functionality; and (ii) enhancement of vascular structures may confound image interpretation. Furthermore, although CE-MRL is well described in the published literature for the lower limbs, there is a paucity of data with regards to its use in the upper limbs. In this proof-of-principle study, we propose a new protocol to perform CE-MRL in the upper limbs of patients with breast cancer-related lymphedema (BCRL) which addresses these limitations. CE-MRL was performed using a previously published (morphological) protocol and the proposed protocol (quantitative) on both the ipsilateral (abnormal) and contralateral (normal) arms of patients with BCRL. The quantitative protocol employs contrast agent (CA) intradermal injections at a lower concentration to prevent T2*-related signal decay. Both protocols provided high-resolution three-dimensional images of upper limb lymphatic vessels. CA uptake curves were utilized to distinguish between lymphatic vessels and vascular structures. The quantitative protocol minimized venous enhancement and avoided spurious delays in lymphatic enhancement due to short T2* values,...Continue Reading

References

Sep 1, 1996·Journal of Biomechanics·P de Leva
Dec 12, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·C L WitteA M Stazzone
May 4, 2004·Magnetic Resonance Imaging·Peter J MoateRaymond C Boston
Oct 19, 2005·Investigative Radiology·Martin RohrerHanns-Joachim Weinmann
Mar 22, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·James A d'ArcyMartin O Leach
Sep 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Billy W LooQuynh-Thu Le
Feb 13, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·P ThévenazM Unser
Mar 1, 2012·The International Journal of Lower Extremity Wounds·Håkan Brorson
Oct 16, 2013·Annals of Plastic Surgery·Takumi YamamotoIsao Koshima
Oct 11, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·M S WeissL D Shea

❮ Previous
Next ❯

Citations

Jun 4, 2016·Lymphatic Research and Biology·Mariana Maia Freire de OliveiraBárbara Juarez Amorim
Jul 28, 2017·Lymphatic Research and Biology·Jacob Hinnerup GroenlundVibeke Hjortdal
Jan 19, 2018·Lymphatic Research and Biology·Svend HvidstenJane A Simonsen
Sep 8, 2017·Lymphatic Research and Biology·Jung Ho Lee, David W Chang
Dec 28, 2018·Plastic and Reconstructive Surgery·Geoffrey E HespeBabak J Mehrara
Jan 14, 2017·Breast Cancer Research and Treatment·Marie-Anne PoumellecTarik Ihrai
Feb 25, 2021·Journal of Magnetic Resonance Imaging : JMRI·Michael MillsFranklyn A Howe
Sep 7, 2020·Advanced Drug Delivery Reviews·Anna K Polomska, Steven T Proulx

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

IDL

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
Boban ThomasRafael Ferreira
© 2021 Meta ULC. All rights reserved