PMID: 6403248Jan 1, 1983Paper

Quantitative coronary angiography during intracoronary streptokinase in acute myocardial infarction: how long to continue thrombolytic therapy?

Catheterization and Cardiovascular Diagnosis
R L FeldmanC J Pepine

Abstract

An intracoronary infusion of streptokinase is often administered in patients with acute myocardial infarction. To address the question of how long intracoronary streptokinase should be infused, we studied 13 patients with symptoms and electrocardiographic findings suggesting an evolving myocardial infarction. We used subselective catheterization techniques and made quantitative angiographic measurements of the percentage of reduction of coronary artery (CA) diameter before intracoronary streptokinase therapy, immediately after reperfusion was established, and at the completion of streptokinase infusion. Before intracoronary streptokinase and after intracoronary nitroglycerin, nine patients had 100% obstruction of the CA in the "infarct-related vessel." In seven patients reperfusion was established (25 +/- 21 min, mean +/- SD) at which time CA diameter was reduced by 77 +/- 22%. The streptokinase infusion was then continued until repeated films (every 10 to 15 min) suggested no further change at the site of CA obstruction (93 +/- 68 min). The percentage of CA diameter reduction when streptokinase infusion was discontinued was 55 +/- 32%; this value was less (P less than 0.05) than that observed early after reperfusion. These dat...Continue Reading

References

Sep 1, 1978·British Heart Journal·R L FeldmanC R Conti
Oct 11, 1979·The New England Journal of Medicine·UNKNOWN European Cooperative Study Group for Streptokinase Treatment in Acute Myocardial Infarction
Jan 1, 1981·American Heart Journal·W GanzH J Swan
Oct 1, 1981·The New England Journal of Medicine·J E MarkisE Braunwald

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