Quantitative CT-derived vessel metrics in idiopathic pulmonary fibrosis: A structure-function study

Respirology : Official Journal of the Asian Pacific Society of Respirology
Joseph JacobHorst Olschewski

Abstract

This study aimed to investigate whether quantitative lung vessel morphology determined by a new fully automated algorithm is associated with functional indices in idiopathic pulmonary fibrosis (IPF). A total of 152 IPF patients had vessel volume, density, tortuosity and heterogeneity quantified from computed tomography (CT) images by a fully automated algorithm. Separate quantitation of vessel metrics in pulmonary arteries and veins was performed in 106 patients. Results were evaluated against readouts from lung function tests. Normalized vessel volume expressed as a percentage of total lung volume was moderately correlated with functional indices on univariable linear regression analysis: forced vital capacity (R2 = 0.27, P < 1 × 10-6 ), diffusion capacity for carbon monoxide (DLCO ; R2 = 0.12, P = 3 × 10-5 ), total lung capacity (TLC; R2 = 0.45, P < 1 × 10-6 ) and composite physiologic index (CPI; R2 = 0.28, P < 1 × 10-6 ). Normalized vessel volume was correlated with vessel density but not with vessel heterogeneity. Quantitatively derived vessel metrics (and artery and vein subdivision scores) were not significantly linked with the transfer factor for carbon monoxide (KCO ), and only weakly with DLCO . On multivariable linea...Continue Reading

References

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Citations

Mar 19, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Peter M George, Athol U Wells
Sep 7, 2020·Methods : a Companion to Methods in Enzymology·Florian PrayerHelmut Prosch

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Methods Mentioned

BETA
X‐ray

Software Mentioned

CALIPER
SPSS Statistics
Chest Imaging Platform
SPSS

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