Quantitative CT evaluation in patients with combined pulmonary fibrosis and emphysema: correlation with pulmonary function

Academic Radiology
Shin MatsuokaYasuo Nakajima

Abstract

The purpose of this study was to evaluate the correlations between objective quantitative computed tomography (CT) measurements of the extent of emphysematous and fibrotic lesions and the results of pulmonary function tests (PFTs) in patients with combined pulmonary fibrosis and emphysema (CPFE). This study involved 43 CPFE patients who underwent CT and PFTs. The extent of emphysematous lesions was obtained by calculating the percentage of low attenuation area (%LAA) values lower than -950 Hounsfield units (HU). Fibrotic lesions were defined as high attenuation area (HAA) using thresholds with pixels between 0 and -700 HU, and the extent of fibrosis was obtained by calculating the percentage of HAA (%HAA). The correlations of %LAA and %HAA with PFTs were evaluated by the Spearman rank correlation coefficients and multiple linear regression analysis. A significant negative correlation was found between %HAA and diffusing capacity of the lung for carbon monoxide (DLco) %predicted (ρ = -0.747; P < .001), whereas no significant correlation was found between %LAA and DLco %predicted. On multiple linear regression analysis, although the %HAA and %LAA were independent contributors to DLco %predicted, the predictive power of %HAA was s...Continue Reading

References

Sep 1, 1991·The American Review of Respiratory Disease·D A SchwartzG W Hunninghake
Jul 1, 1996·American Journal of Respiratory and Critical Care Medicine·P A GevenoisJ C Yernault
Oct 6, 2005·The European Respiratory Journal·V CottinUNKNOWN Groupe d'Etude et de Recherche sur les Maladies Orphelines Pulmonaires (GERM O P)
Aug 9, 2007·Respiration; International Review of Thoracic Diseases·Matthew D JankowichSharon Rounds
Jan 7, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yoshiaki KitaguchiKeishi Kubo
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis

❮ Previous
Next ❯

Citations

Jul 7, 2017·The European Respiratory Journal·Joseph JacobAthol U Wells
Nov 2, 2016·The European Respiratory Journal·Anna J PodolanczukDavid J Lederer
Apr 18, 2020·Radiology·Davide ColombiEmanuele Michieletti
Jul 13, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Joseph JacobAthol U Wells
Jan 17, 2020·Scientific Reports·David Bermejo-PeláezMaría J Ledesma-Carbayo
Jun 29, 2017·American Journal of Respiratory and Critical Care Medicine·Vincent CottinAthol U Wells
Feb 11, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·L BertaA Torresin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.