Abstract
Hair of young subjects (N = 36) suspected for drug abuse was analysed for morphine, codeine, heroin, 6-acetylmorphine, cocaine, methadone, amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA). The analysis of morphine, codeine, heroin, 6-acetylmorphine, cocaine, and methadone in hair included incubation in methanol, solid-phase extraction, derivatisation by the mixture of propionic acid anhydride and pyridine, and gas chromatography/mass spectrometry (GC/MS). For amphetamine, methamphetamine, MDA, MDMA, and MDEA analysis, hair samples were incubated in 1M sodium hydroxide, extracted with ethyl acetate, derivatised with heptafluorobutyric acid anhydride (HFBA), and assayed by GC/MS. The methods were reproducible (R.S.D. = 5.0-16.1%), accurate (85.1-100.6%), and sensitive (LoD = 0.05-0.30ng/mg). The applied methods confirmed consumption of heroin in 18 subjects based on positive 6-acetylmorphine. Among these 18 heroin consumers, methadone was found in four, MDMA in two, and cocaine in two subjects. Cocaine only was present in two, methadone only in two, methamphetamine only in two, and MDMA only in seven of the 36 subjects. In tw...Continue Reading
References
Jan 1, 1992·Journal of Analytical Toxicology·E M ThurmanT Martin
Sep 1, 1991·Journal of Analytical Toxicology·B A GoldbergerE J Cone
Sep 1, 1995·Journal of Analytical Toxicology·V CirimeleP Mangin
May 22, 1995·Forensic Science International : Synergy·P Kintz, P Mangin
Jan 5, 1995·Forensic Science International : Synergy·C JuradoM Repetto
Dec 1, 1993·Forensic Science International : Synergy·M R MoellerR Wennig
Dec 1, 1993·Forensic Science International : Synergy·M R MoellerH Sachs
Dec 1, 1993·Forensic Science International : Synergy·E J ConeW L Wang
Jul 1, 1995·Journal of Analytical Toxicology·M Rothe, F Pragst
Aug 15, 1996·Forensic Science International : Synergy·L Pötsch, G Skopp
Jan 17, 1997·Forensic Science International : Synergy·G SkoppM R Moeller
Jan 17, 1997·Forensic Science International : Synergy·P Kintz, V Cirimele
Apr 18, 1997·Forensic Science International : Synergy·Y Gaillard, G Pépin
Jan 1, 1997·International Journal of Legal Medicine·C JuradoM Repetto
Mar 26, 1998·Journal of Chromatographic Science·K M HöldE J Cone
May 29, 1998·Journal of Analytical Toxicology·P KintzB Ludes
Aug 13, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·J SeguraC Jurado
Apr 15, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·J SeguraM Montagna
Nov 26, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·Y Nakahara
Citations
Sep 27, 2003·Phytochemical Analysis : PCA
Nov 10, 2006·Analytical and Bioanalytical Chemistry·Shinichi NakamuraKenichiro Nakashima
Mar 21, 2007·Analytical and Bioanalytical Chemistry·Teresa Gray, Marilyn Huestis
May 9, 2007·Analytical and Bioanalytical Chemistry·Frank Musshoff, Burkhard Madea
Mar 3, 2010·Analytical and Bioanalytical Chemistry·M BarrosoJ A Queiroz
Jan 28, 2012·Analytical and Bioanalytical Chemistry·Kevin Y ZhuKarl W K Tsim
Dec 4, 2003·Forensic Science International : Synergy·F S RomoloA Lopez
Dec 4, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Fernanda Crossi Pereira de ToledoOvandir Alves Silva
Mar 8, 2014·Analytical and Bioanalytical Chemistry·Yuan-Jhe ChangYan-Zin Chang
Jun 8, 2013·Bioanalysis·Gilberto AlvesJoão Queiroz
Jul 13, 2004·International Journal of Legal Medicine·Fabio De GiorgioMarcello Chiarotti
Apr 20, 2010·Analytical and Bioanalytical Chemistry·P LópezM Chiarotti
May 25, 2013·Analytical and Bioanalytical Chemistry·Marcela Nogueira Rabelo AlvesAldo Polettini
Jul 24, 2010·Forensic Science International : Synergy·SeungKyung BaeckMyoungYun Pyo
May 27, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·P FernándezM J Tabernero
Jul 1, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ya-Hsueh WuYan-Zin Chang
Apr 9, 2008·Journal of Pharmaceutical and Biomedical Analysis·Laura MercoliniMaria Augusta Raggi
Feb 24, 2007·Journal of Chromatography. a·Yi-Hui LinShou-Mei Wu
Apr 30, 2003·Biomedical Chromatography : BMC·Nariaki TakayamaKazuichi Hayakawa
Jun 17, 2006·Biomedical Chromatography : BMC·Shinichi NakamuraKenichiro Nakashima
Feb 22, 2008·Rapid Communications in Mass Spectrometry : RCM·Ya-Hsueh WuYan-Zin Chang
May 29, 2008·Biomedical Chromatography : BMC·E Gallardo, J A Queiroz
Feb 13, 2007·Biomedical Chromatography : BMC·C GambelungheM Bacci
Nov 10, 2010·Biomedical Chromatography : BMC·Stacy D Brown, Tyler C Melton
Nov 16, 2004·Forensic Science International : Synergy·Eunyoung HanHeesun Chung
Jul 28, 2006·Forensic Science International : Synergy·Eunyoung HanHeesun Chung
Aug 23, 2006·Journal of Separation Science·Agnieszka KaletaWolfgang Buchberger
Jan 1, 2014·Forensic Science International : Synergy·L ImbertJ-M Gaulier
Mar 25, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Liang MengKefang Zheng
Jan 22, 2015·Analytica Chimica Acta·Susanna VogliardiDonata Favretto
Aug 29, 2007·Analytica Chimica Acta·Ahai C LuaTsong-Yung Chou
Apr 20, 2016·Journal of Separation Science·Arezou TaghvimiMahmoud Ebrahimi
Dec 13, 2006·Forensic Science International : Synergy·Stacy D BrownBoyd J Pritchard
Oct 23, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Sys Stybe Johansen, Jakob Jornil
Apr 24, 2018·Medicine, Science, and the Law·Himanshu KhajuriaAshish Badiye
Aug 21, 2019·BMC Chemistry·Iltaf ShahDeclan P Naughton
Jul 23, 2019·Journal of Analytical Toxicology·Tiago RosadoEugenia Gallardo
Jan 1, 2015·BioImpacts : BI·Sonu GandhiC Raman Suri
May 2, 2018·BioImpacts : BI·Smritee SinghSonu Gandhi
May 5, 2020·Journal of Analytical Toxicology·T RosadoM Barroso
Nov 16, 2017·Analytica Chimica Acta·Pegah HashemiTayyebeh Madrakian
Aug 30, 2003·Analytical Chemistry·T A BrettellR Saferstein