PMID: 11909652Mar 23, 2002Paper

Quantitative determination of amphetamines, cocaine, and opiates in human hair by gas chromatography/mass spectrometry

Forensic Science International : Synergy
L SkenderA Bagarić

Abstract

Hair of young subjects (N = 36) suspected for drug abuse was analysed for morphine, codeine, heroin, 6-acetylmorphine, cocaine, methadone, amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA). The analysis of morphine, codeine, heroin, 6-acetylmorphine, cocaine, and methadone in hair included incubation in methanol, solid-phase extraction, derivatisation by the mixture of propionic acid anhydride and pyridine, and gas chromatography/mass spectrometry (GC/MS). For amphetamine, methamphetamine, MDA, MDMA, and MDEA analysis, hair samples were incubated in 1M sodium hydroxide, extracted with ethyl acetate, derivatised with heptafluorobutyric acid anhydride (HFBA), and assayed by GC/MS. The methods were reproducible (R.S.D. = 5.0-16.1%), accurate (85.1-100.6%), and sensitive (LoD = 0.05-0.30ng/mg). The applied methods confirmed consumption of heroin in 18 subjects based on positive 6-acetylmorphine. Among these 18 heroin consumers, methadone was found in four, MDMA in two, and cocaine in two subjects. Cocaine only was present in two, methadone only in two, methamphetamine only in two, and MDMA only in seven of the 36 subjects. In tw...Continue Reading

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Citations

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Dec 4, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Fernanda Crossi Pereira de ToledoOvandir Alves Silva
Jul 13, 2004·International Journal of Legal Medicine·Fabio De GiorgioMarcello Chiarotti
Apr 20, 2010·Analytical and Bioanalytical Chemistry·P LópezM Chiarotti
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Jul 24, 2010·Forensic Science International : Synergy·SeungKyung BaeckMyoungYun Pyo
May 27, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·P FernándezM J Tabernero
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