Quantitative determination of risperidone, paliperidone and olanzapine in human serum by liquid chromatography-tandem mass spectrometry coupled with on-line solid-phase extraction

Biomedical Chromatography : BMC
Can-Jun RuanJose de Leon

Abstract

A recent guideline recommends therapeutic drug monitoring for risperidone, paliperidone and olanzapine, which are frequently used second-generation antipsychotics. We developed a simple high-performance liquid chromatography-tandem mass spectrometry coupled with an online solid-phase extraction method that can be used to measure risperidone, paliperidone and olanzapine using small (40 μL) samples. The analytes were extracted from serum samples automatically pre-concentrated and purified by C8 (5 μm, 2.1 × 30 mm) solid-phase extraction cartridges, then chromatographed on an Xbidge™ C18 column (3.5 μm, 100 × 2.1 mm) thermostatted at 30°C with a mobile phase consisting of 70% acetonitrile and 30% ammonium hydroxide 1% solution at an isocratic flow rate of 0.3 mL/min, and detected with tandem mass spectrometry. The assay was validated in the concentration range from 2.5 to 160 ng/mL. Intra- and inter-day precision for all analytes was between 1.1 and 8.2%; method accuracy was between 6.6 and 7.6%. The risperidone and paliperidone assay was compared with a high-performance liquid chromatography-ultraviolet assay currently used in our hospital for risperidone and paliperidone therapeutic drug monitoring, and the results of weighted D...Continue Reading

References

Feb 1, 1994·Psychopharmacology·A A MegensJ E Leysen
Oct 8, 1999·Clinical Pharmacokinetics·J T CallaghanC M Beasley
Nov 20, 2004·Pharmacopsychiatry·P BaumannUNKNOWN Arbeitsge-meinschaft fur neuropsychopharmakologie und pharmakopsychiatrie
Sep 24, 2009·Journal of Chromatographic Science·Ligang ChenLan Ding
Feb 2, 2010·Psychosomatics·Jose de LeonNeil B Sandson
Dec 25, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Roberto MandrioliMaria Augusta Raggi
Sep 9, 2011·Bioanalysis·Nadia Y Ashri, Mohamed Abdel-Rehim
Nov 20, 2012·Forensic Science International : Synergy·Paula ProençaDuarte Nuno Vieira
Sep 10, 2014·Journal of Neural Transmission·Edoardo Spina, Jose de Leon
Sep 15, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Cristina SempioAngelo Groppi
Jan 14, 2016·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Pavel SistikPetr Bednar
May 2, 2017·The American Journal of Psychiatry·Marcela Horvitz-LennonOliver D Howes
Jul 4, 2017·Psychosomatics·Can-Jun RuanJose de Leon
Jul 13, 2017·Expert Review of Clinical Pharmacology·Georgios SchoretsanitisJose de Leon

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Citations

Jan 22, 2019·Bioanalysis·Maria Eugênia Costa QueirozJaime E Cecilio Hallak
Aug 28, 2020·Frontiers in Pharmacology·Yuanxia CuiWeihua Yue

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