Quantitative determination of T cells in ocular lymphoid infiltrates. An indirect method for distinguishing between pseudolymphomas and malignant lymphomas

Archives of Ophthalmology
D M Knowles, F A Jakobiec

Abstract

T lymphocytes may be identified by two comparatively simple techniques: sheep erythrocyte (E) rosette formation and cytochemically demonstrable acid alpha-naphthyl acetate esterase (ANAE) activity. We tested the quantitative determination of T cells in 17 ocular lymphoid tumors as an indirect method for characterizing their clonality. Six lesions containing greater than 40% T cells (47% to 73%; mean, 62%) were shown to be polyclonal proliferations and were classified as pseudolymphomas by histologic criteria. Seven lesions containing less than 30% T cells (3% to 20%; mean, 10%) were shown to be monoclonal B-cell proliferations and were classified as malignant lymphomas by histologic criteria. Only two lesions containing between 30% and 40% T cells could not be unequivocally assigned to the monoclonal or polyclonal category solely based on the percentage of T cells. In the final two lesions, the tissue specimen was too small to allow a full panel of immunologic studies; both tumors showed a predominance of T cells consistent with their benign histologic features.

Citations

Aug 1, 1982·American Journal of Ophthalmology·J H YeoS L Trokel
Dec 1, 1984·The British Journal of Ophthalmology·R van der GaagT E Feltkamp
Jan 1, 1988·Eye·R van der Gaag
Dec 3, 2016·The British Journal of Ophthalmology·Adel G AlAkeelyDeepak P Edward
Feb 18, 2011·Medical Oncology·Tadashi Terada

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.