journal cover

Quantitative dissection of the simple repression input-output function

Proceedings of the National Academy of Sciences of the United States of America

Jul 7, 2011

Hernan G Garcia, Rob Phillips

Abstract

We present a quantitative case study of transcriptional regulation in which we carry out a systematic dialogue between theory and measurement for an important and ubiquitous regulatory motif in bacteria, namely, that of simple repression. This architecture is realized by a single repres...read more

Mentioned in this Paper

Thermodynamics
Transcriptional Regulation
Lac Repressors
Immunoblotting, Reverse
Transcription Repressor/Corepressor
Alkalescens-Dispar Group
Mutagenesis, Site-Directed
Promoter
Gene Expression
Ligand Binding Domain
150
Paper Details
References
  • References44
  • Citations43
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  • References44
  • Citations43
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Quantitative dissection of the simple repression input-output function

Proceedings of the National Academy of Sciences of the United States of America

Jul 7, 2011

Hernan G Garcia, Rob Phillips

PMID: 21730194

DOI: 10.1073/pnas.1015616108

Abstract

We present a quantitative case study of transcriptional regulation in which we carry out a systematic dialogue between theory and measurement for an important and ubiquitous regulatory motif in bacteria, namely, that of simple repression. This architecture is realized by a single repres...read more

Mentioned in this Paper

Thermodynamics
Transcriptional Regulation
Lac Repressors
Immunoblotting, Reverse
Transcription Repressor/Corepressor
Alkalescens-Dispar Group
Mutagenesis, Site-Directed
Promoter
Gene Expression
Ligand Binding Domain
150

Similar Papers Found In These Feeds

Transcriptional Condensates (Keystone)

Enhancers are DNA elements that are bound by transcription factors (TFs). These DNA sequences can drive condensation of TFs and coactivators. Here is the latest research on transcriptional condensates.

PNAS - Microbiology

The Proceedings of the National Academy of Sciences (PNAS) is a peer-reviewed multidisciplinary scientific journal. Here are the latest research papers from PNAS.

Related Papers

Current Opinion in Genetics & Development

Transcriptional regulation by the numbers: models

Current Opinion in Genetics & DevelopmentMarch 31, 2005
Lacramioara BintuRob Phillips
Molecular Cell

Mode of regulation and the insulation of bacterial gene expression

Molecular CellMay 29, 2012
Vered SassonUri Alon
Paper Details
References
  • References44
  • Citations43
12345
  • References44
  • Citations43
12345
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