PMID: 3763440Jul 1, 1986Paper

Quantitative distribution of angiotensin II binding sites in rat brain by autoradiography

Peptides
J M SaavedraF M Correa

Abstract

Angiotensin II binding sites were localized and quantified in individual brain nuclei from single rats by incubation of tissue sections with 1 nM 125I-[Sar1]-angiotensin II, [3H]-Ultrofilm autoradiography, computerized microdensitometry and comparison with 125I-standards. High angiotensin II binding was present in the circumventricular organs (organon vasculosum laminae terminalis, organon subfornicalis and area postrema), in selected hypothalamic nuclei (nuclei suprachiasmatis, periventricularis and paraventricularis) and in the nucleus tractus olfactorii lateralis, the nucleus preopticus medianus, the dorsal motor nucleus of the vagus and the nucleus tractus solitarii. High affinity (KA from 0.3 to 1.5 X 10(9) M-1) angiotensin II binding sites were demonstrated in the organon subfornicalis, the nucleus tractus solitarii and the area postrema after incubation of consecutive sections from single rat brains with 125I-[Sar1]-angiotensin II in concentrations from 100 pM to 5 nM. These results demonstrate and characterize brain binding sites for angiotensin II of variable high affinity binding both inside and outside the blood-brain barrier.

References

Feb 18, 1977·Brain Research·N E SirettJ I Hubbard
Jul 1, 1985·Regulatory Peptides·A IsraelJ M Saavedra
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L M Plunkett, J M Saavedra
Jun 1, 1970·The American Journal of Physiology·J P Bonjour, R L Malvin
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·F K Stephan, I Zucker
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·A IsraelJ M Saavedra
Jul 1, 1982·Journal of Neuroscience Methods·J R UnnerstallJ M Palacios
Jan 1, 1980·Reviews of Physiology, Biochemistry and Pharmacology·J T Fitzsimons
Feb 2, 1981·Brain Research·J W HardingJ W Wright
Jan 1, 1982·Journal of Neurochemistry·C Chevillard, J M Saavedra
Aug 1, 1982·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·M Herkenham, C B Pert
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·F A MendelsohnK J Catt
Feb 10, 1984·Neuroscience Letters·D P Healy, M P Printz
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F A MendelsohnK J Catt
Jul 1, 1984·Hypertension·K L Barnes, C M Ferrario
Mar 1, 1983·Brain Research Bulletin·J A TonnaerW de Jong

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Citations

Jun 1, 1987·Cellular and Molecular Neurobiology·J M Saavedra
Aug 3, 2005·Cellular and Molecular Neurobiology·Juan M Saavedra
Jan 4, 1994·European Journal of Pharmacology·M Cierco, A Israel
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·J W Wright, J W Harding
Jan 1, 1989·Brain Research. Brain Research Reviews·S M Gardiner, T Bennett
Nov 10, 1995·Regulatory Peptides·J W Wright, J W Harding
Mar 1, 1992·Peptides·W Kloas, W Hanke
Nov 1, 1988·Neuroscience·E Garcia-Rill, R D Skinner
Jun 1, 1987·Brain Research Bulletin·E Garcia-RillD J Woodward
Nov 25, 1997·Brain Research. Brain Research Reviews·J W Wright, J W Harding
Jul 9, 2004·Annals of the New York Academy of Sciences·J M SaavedraJ Zhou
Apr 20, 2005·Regulatory Peptides·Juan M SaavedraMiroslava Macova
Jul 1, 1993·Clinical and Experimental Hypertension : CHE·C Y ChaiD Ganten
Jan 13, 2004·Physiological Reviews·José Antunes-RodriguesSamuel M McCann
Sep 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·A Jean
Jun 27, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Michele IovinoVincenzo Triggiani

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